PMID- 17729041
OWN - NLM
STAT- MEDLINE
DCOM- 20071213
LR  - 20131121
IS  - 0891-6934 (Print)
IS  - 0891-6934 (Linking)
VI  - 40
IP  - 6
DP  - 2007 Sep
TI  - Regulation of dendritic cells by female sex steroids: relevance to immunity and 
      autoimmunity.
PG  - 470-81
AB  - Dendritic cells (DCs) are critical mediators of adaptive immunity, tolerance and 
      autoimmunity. The human immune system exhibits sexual dimorphism, which is most 
      evident in the female predominance of autoimmune diseases such as systemic lupus 
      erythematosus (SLE). Female sex steroids are strongly implicated in mediating 
      immune sexual dimorphism, in part because estrogen accentuates disease in several 
      models of lupus autoimmunity. In contrast, progesterone may prevent disease 
      development. While much investigation has focused on the effects of estrogen and 
      progesterone on lymphocyte functions, far less attention has been paid to the 
      effects of these hormones on DCs. Current evidence now indicates estrogen can 
      activate DCs, while in contrast, progesterone inhibits DC functions. Thus, we 
      hypothesize that the opposite effects these two hormones have on lupus 
      autoimmunity reflect opposing effects on DC functions. Thus, through direct 
      actions on DCs, female sex steroids may influence autoimmunity, immunity and 
      tolerance.
FAU - Hughes, Grant C
AU  - Hughes GC
AD  - Division of Rheumatology, Department of Medicine, University of Washington, 
      Seattle, WA 98195, USA. hughesg@u.washington.edu
FAU - Clark, Edward A
AU  - Clark EA
LA  - eng
GR  - AI44257/AI/NIAID NIH HHS/United States
GR  - AI52203/AI/NIAID NIH HHS/United States
GR  - AR7108/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (Cytokines)
RN  - 0 (Estrogens)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - *Autoimmunity
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Estrogens/*physiology
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Male
MH  - Progesterone/*physiology
MH  - Sex Characteristics
RF  - 139
EDAT- 2007/08/31 09:00
MHDA- 2007/12/14 09:00
CRDT- 2007/08/31 09:00
PHST- 2007/08/31 09:00 [pubmed]
PHST- 2007/12/14 09:00 [medline]
PHST- 2007/08/31 09:00 [entrez]
AID - 781650084 [pii]
AID - 10.1080/08916930701464764 [doi]
PST - ppublish
SO  - Autoimmunity. 2007 Sep;40(6):470-81. doi: 10.1080/08916930701464764.