PMID- 1773004
OWN - NLM
STAT- MEDLINE
DCOM- 19920304
LR  - 20131121
IS  - 0957-5235 (Print)
IS  - 0957-5235 (Linking)
VI  - 2
IP  - 1
DP  - 1991 Feb
TI  - Reocclusion after thrombolysis: a problem solved by hirudin?
PG  - 97-100
AB  - The effect of recombinant hirudin (r-hir), unfractionated heparin (UFH) and 
      acetylsalicylic acid (ASA) on the incidence of reocclusion after thrombolysis 
      with plasminogen activator (rt-PA) was evaluated in anaesthetized rabbits. 
      Formation of a platelet rich thrombus was achieved by implantation of a copper 
      coil into the iliac artery. The occluded artery was recanalized in six of ten 
      animals by intravenous administration of rt-PA given as a bolus injection of 0.1 
      mg/kg followed by infusion of 0.5 mg/kg/h. Within 1 h after termination of rt-PA 
      infusion rethrombosis was observed in 100% of recanalized vessels. The incidence 
      of reocclusion was diminished by r-hir in a dose-dependent manner to 50% after 
      infusion of 0.05 mg/kg/h and to 25% after 0.1 mg/kg/h. No effect on APTT was 
      detectable in this dosage after 3 h infusion. UFH in a dosage increasing APTT 
      two-fold (35 U/kg/h) did not reduce the reocclusion rate. 100 U/kg/h UFH 
      increased APTT to greater than 3 min and reduced reocclusion rates to 50%. ASA 
      showed a minor effect on the incidence of restenosis whereas the combination of 
      0.1 mg/kg/h r-hir plus bolus injection of 10 mg/kg ASA led to a further reduction 
      in reocclusion rates to only 11% and an increase in reperfusion rates from 60 to 
      90%. Our experiments indicate that the combination of plasminogen activator with 
      r-hir may be a useful approach for the prophylaxis of early reocclusion.
FAU - Rubsamen, K
AU  - Rubsamen K
AD  - Knoll AG, Department of Angiology, Ludwigshafen, Germany.
FAU - Eschenfelder, V
AU  - Eschenfelder V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and 
      thrombosis
JID - 9102551
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Hirudins)
RN  - 0 (Recombinant Proteins)
RN  - 138361-64-5 (LU 52369)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Animals
MH  - Aspirin/pharmacology/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Fibrinolytic Agents/pharmacology/*therapeutic use
MH  - Heparin/pharmacology/therapeutic use
MH  - Hirudin Therapy
MH  - Hirudins/*analogs & derivatives/pharmacology
MH  - Iliac Artery
MH  - Partial Thromboplastin Time
MH  - Rabbits
MH  - Recombinant Proteins/pharmacology/therapeutic use
MH  - Recurrence
MH  - Reperfusion
MH  - *Thrombolytic Therapy
MH  - Thrombosis/drug therapy/*prevention & control
MH  - Tissue Plasminogen Activator/*therapeutic use
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 1991 Feb;2(1):97-100.