PMID- 1773350
OWN - NLM
STAT- MEDLINE
DCOM- 19920228
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 565
IP  - 1
DP  - 1991 Nov 22
TI  - Activation of tuberoinfundibular and tuberohypophysial dopamine neurons following 
      intracerebroventricular administration of bombesin.
PG  - 142-7
AB  - The effect of bombesin on the activity of dopamine (DA) neurons comprising the 
      nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophysial systems in 
      the male rat was determined by measuring: (1) the accumulation of 
      3,4-dihydroxyphenylalanine (DOPA) after administration of a decarboxylase 
      inhibitor, and (2) the concentration of the DA metabolite 
      3,4-dihydroxyphenylacetic acid (DOPAC) in brain (striatum, nucleus accumbens, 
      median eminence) and pituitary regions (intermediate and neural lobes) containing 
      terminals of these neurons. Intracerebroventricular (i.c.v.) injection of 
      bombesin caused a dose- and time-related increase in the activity of DA neurons 
      projecting to the median eminence and intermediate lobe of the pituitary, and a 
      corresponding decrease in the concentrations of prolactin and 
      alpha-melanocyte-stimulating hormone (alpha MSH) in the plasma. In contrast, 
      doses of bombesin up to 10 ng i.c.v. failed to alter the activity of DA neurons 
      terminating in the striatum, nucleus accumbens or neural lobe of the pituitary 
      gland. Equimolar doses of bombesin and gastrin-releasing peptide (GRP), a 
      bombesin-like peptide, increased the concentrations of DOPAC in the median 
      eminence and intermediate lobe of the pituitary, suggesting that GRP-preferring 
      receptors may be responsible for the stimulatory effects of bombesin on DA 
      neuronal activity in these regions. The results of these studies suggest that 
      bombesin increases the activity of tuberoinfundibular and tuberohypophysial DA 
      neurons projecting to the median eminence and intermediate lobe of the pituitary, 
      respectively, and thereby inhibits the secretion of prolactin and alpha MSH.
FAU - Manzanares, J
AU  - Manzanares J
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing 48824.
FAU - Toney, T W
AU  - Toney TW
FAU - Lookingland, K J
AU  - Lookingland KJ
FAU - Moore, K E
AU  - Moore KE
LA  - eng
GR  - MH 42802/MH/NIMH NIH HHS/United States
GR  - NS 15911/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-79-3 (Melanocyte-Stimulating Hormones)
RN  - PX9AZU7QPK (Bombesin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Bombesin/administration & dosage/*pharmacology
MH  - Brain/drug effects/*metabolism
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraventricular
MH  - Median Eminence/drug effects/metabolism
MH  - Melanocyte-Stimulating Hormones/blood/metabolism
MH  - Neurons/drug effects/*physiology
MH  - Organ Specificity
MH  - Pituitary Gland/drug effects/*metabolism
MH  - Prolactin/blood/metabolism
MH  - Reference Values
EDAT- 1991/11/22 00:00
MHDA- 1991/11/22 00:01
CRDT- 1991/11/22 00:00
PHST- 1991/11/22 00:00 [pubmed]
PHST- 1991/11/22 00:01 [medline]
PHST- 1991/11/22 00:00 [entrez]
AID - 0006-8993(91)91745-M [pii]
AID - 10.1016/0006-8993(91)91745-m [doi]
PST - ppublish
SO  - Brain Res. 1991 Nov 22;565(1):142-7. doi: 10.1016/0006-8993(91)91745-m.