PMID- 1773809
OWN - NLM
STAT- MEDLINE
DCOM- 19920303
LR  - 20190828
IS  - 0301-5548 (Print)
IS  - 0301-5548 (Linking)
VI  - 63
IP  - 5
DP  - 1991
TI  - The influence of dietary manipulation on plasma ammonia accumulation during 
      incremental exercise in man.
PG  - 338-44
AB  - The influence of a pattern of exercise and dietary manipulation, intended to 
      alter carbohydrate (CHO) availability, on pre-exercise acid-base status and 
      plasma ammonia and blood lactate accumulation during incremental exercise was 
      investigated. On three separate occasions, five healthy male subjects underwent a 
      pre-determined incremental exercise test (IET) on an electrically braked cycle 
      ergometer. Each IET involved subjects exercising for 5 min at 30%, 50%, 70% and 
      95% of their maximal oxygen uptake (VO2max) and workloads were separated by 5 min 
      rest. The first IET took place after 3 days of normal dietary CHO intake. The 
      second and third tests followed 3 days of low or high CHO intake, which was 
      preceded by prolonged exercise to exhaustion in an attempt to deplete muscle and 
      liver glycogen stores. Acid-base status and plasma ammonia and blood lactate 
      levels were measured on arterialised venous blood samples immediately prior to 
      and during the final 15 s of exercise at each workload and for 40 min following 
      the completion of each IET. Three days of low CHO intake resulted in the 
      development of a mild metabolic acidosis in all subjects. Plasma ammonia (NH3) 
      accumulation on the low-CHO diet tended to be greater than normal at each 
      exercise workload. Values returned towards resting levels during each recovery 
      period. After the normal and high-CHO diets plasma NH3 levels did not markedly 
      increase above resting values until after exercise at 95% VO2max. Plasma NH3 
      levels after the high-CHO diet were similar to those after the normal CHO 
      diet.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Greenhaff, P L
AU  - Greenhaff PL
AD  - Department of Environmental and Occupational Medicine, University Medical School, 
      Aberdeen, UK.
FAU - Leiper, J B
AU  - Leiper JB
FAU - Ball, D
AU  - Ball D
FAU - Maughan, R J
AU  - Maughan RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Appl Physiol Occup Physiol
JT  - European journal of applied physiology and occupational physiology
JID - 0410266
RN  - 0 (Dietary Carbohydrates)
RN  - 7664-41-7 (Ammonia)
SB  - IM
MH  - Acid-Base Equilibrium/physiology
MH  - Adult
MH  - Ammonia/*blood
MH  - Blood Volume/physiology
MH  - *Diet
MH  - Dietary Carbohydrates/pharmacology
MH  - Exercise/*physiology
MH  - Humans
MH  - Male
MH  - Oxygen Consumption/drug effects
MH  - Physical Exertion/physiology
MH  - Time Factors
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1007/BF00364459 [doi]
PST - ppublish
SO  - Eur J Appl Physiol Occup Physiol. 1991;63(5):338-44. doi: 10.1007/BF00364459.