PMID- 17761456
OWN - NLM
STAT- MEDLINE
DCOM- 20081203
LR  - 20171116
IS  - 1389-9457 (Print)
IS  - 1389-9457 (Linking)
VI  - 9
IP  - 5
DP  - 2008 Jul
TI  - Clinical characteristics and HLA typing of a family with Kleine-Levin syndrome.
PG  - 575-8
AB  - BACKGROUND: Kleine-Levin syndrome (KLS) is a rare disorder of unknown etiology. 
      To date, only four familial cases have been described. The possible presence of 
      genetic and autoimmune processes has been postulated recently. Our objective was 
      to report for the first time a multiplex KLS Saudi family with 6 out of 12 family 
      members affected. METHODS: The demographic and clinical features of the six 
      affected family members are described. KLS was diagnosed according to the 
      International Classification of Sleep Disorders (ICSD). Human leukocyte antigen 
      (HLA) typing was performed for both affected and unaffected family members and 
      compared to previous studies. RESULTS: The father and three male and two female 
      children were affected. Age of onset ranged from 15 to 21 years. Symptoms 
      disappeared in four family members. HLA typing was identical in the father and 
      two children (1F and 5M). All affected members shared one-half of HLA antigens. 
      HLA typing revealed that four members out of the six affected members are 
      homozygous at DQB1 *02 loci. CONCLUSIONS: This report provides a description of a 
      multiplex KLS family with six members affected. HLA-DQB1 *02 homozygosity was 
      present in 4/6 affected and 2/6 unaffected family members. The family studied 
      presents an invaluable opportunity for further DNA and genetic studies, which may 
      help in finding the mutation in the future.
FAU - BaHammam, Ahmed S
AU  - BaHammam AS
AD  - Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia. ashammam2@gmail.com
FAU - GadElRab, Mohamed O
AU  - GadElRab MO
FAU - Owais, Suriya M
AU  - Owais SM
FAU - Alswat, Khalid
AU  - Alswat K
FAU - Hamam, Khalid D
AU  - Hamam KD
LA  - eng
PT  - Journal Article
DEP - 20070829
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Female
MH  - Genetic Carrier Screening
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - *Histocompatibility Testing
MH  - Homozygote
MH  - Humans
MH  - Kleine-Levin Syndrome/*genetics
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Young Adult
EDAT- 2007/09/01 09:00
MHDA- 2008/12/17 09:00
CRDT- 2007/09/01 09:00
PHST- 2006/11/21 00:00 [received]
PHST- 2007/06/27 00:00 [revised]
PHST- 2007/06/29 00:00 [accepted]
PHST- 2007/09/01 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2007/09/01 09:00 [entrez]
AID - S1389-9457(07)00257-2 [pii]
AID - 10.1016/j.sleep.2007.06.015 [doi]
PST - ppublish
SO  - Sleep Med. 2008 Jul;9(5):575-8. doi: 10.1016/j.sleep.2007.06.015. Epub 2007 Aug 
      29.