PMID- 17761923
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20161122
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 38
IP  - 10
DP  - 2007 Oct
TI  - The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among 
      survivors of aneurysmal subarachnoid hemorrhage.
PG  - 2858-60
AB  - BACKGROUND AND PURPOSE: Brain-derived neurotrophic factor (BDNF) plays a role in 
      neuronal survival, plasticity and neurogenesis. The BDNF gene contains a common 
      Val66Met polymorphism; the Met allele is associated with lower 
      depolarization-induced BDNF release and differences in memory functions and brain 
      morphology. We hypothesized that the Met allele is associated with poor recovery 
      from subarachnoid hemorrhage. METHODS: A sample of 105 survivors was assessed at 
      3 months after subarachnoid hemorrhage using Glascow Outcome Scale. Poor outcome 
      was defined as severe disability or worse. DNA samples were genotyped for the 
      Val66Met polymorphism. RESULTS: Higher percentage of the Met carriers had a poor 
      outcome (29%) as compared with the Val/Val group (10%; P=0.011). In multiple 
      logistic regression, this association between the Met allele and poor outcome was 
      independent of several other prognostic factors such as patient age, clinical 
      condition, and radiological severity of the bleeding (odds ratio 8.40; 95% CI, 
      1.60 to 44.00; P=0.012). CONCLUSIONS: Genetically influenced variation in BDNF 
      function plays a role in recovery from subarachnoid hemorrhage. These data 
      indicate that augmentation of BDNF signaling may be beneficial to recovery from 
      brain injury.
FAU - Siironen, Jari
AU  - Siironen J
FAU - Juvela, Seppo
AU  - Juvela S
FAU - Kanarek, Katarzyna
AU  - Kanarek K
FAU - Vilkki, Juhani
AU  - Vilkki J
FAU - Hernesniemi, Juha
AU  - Hernesniemi J
FAU - Lappalainen, Jaakko
AU  - Lappalainen J
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070830
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Predictive Value of Tests
MH  - Recovery of Function
MH  - Subarachnoid Hemorrhage/*genetics/*physiopathology
EDAT- 2007/09/01 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/09/01 09:00
PHST- 2007/09/01 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/09/01 09:00 [entrez]
AID - STROKEAHA.107.485441 [pii]
AID - 10.1161/STROKEAHA.107.485441 [doi]
PST - ppublish
SO  - Stroke. 2007 Oct;38(10):2858-60. doi: 10.1161/STROKEAHA.107.485441. Epub 2007 Aug 
      30.