PMID- 17762268
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20131121
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 117
IP  - 8
DP  - 2007 Aug
TI  - Effects of dexamethasone on the expression of transforming growth factor-beta in 
      the mouse model of allergic rhinitis.
PG  - 1323-8
AB  - OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the effect of dexamethasone 
      on the expression of transforming growth factor (TGF)-beta in the mouse model of 
      allergic rhinitis. STUDY DESIGN: Female BALB/c mice were randomly assigned to 
      four groups, including two control groups and two treatment groups. METHODS: 
      General sensitization and local challenge were performed with ovalbumin (OVA). In 
      the treatment groups, dexamethasone was injected intraperitoneally 3 hours before 
      general sensitization or local challenge. Symptom score, eosinophil infiltration, 
      and immunostaining for TGF-beta1 and CD4 in nasal mucosa, and TGF-beta1 and 
      OVA-specific immunoglobulin E (IgE) in sera were analyzed. RESULTS: Dexamethasone 
      administration before general sensitization reduced the symptom score, 
      OVA-specific IgE, and eosinophil infiltration and increased the serum level of 
      TGF-beta1 significantly. Dexamethasone administration before local challenge 
      reduced only the eosinophil infiltration significantly. Immunoreactivity of 
      TGF-beta1 and CD4 was lower in both treatment groups. CONCLUSION: These results 
      suggest that dexamethasone may play an important role in the regulation of 
      allergic reactions by at least two mechanisms; one by suppressing allergic 
      sensitization through decrease of CD4+ T cells and increase of TGF-beta, and the 
      other by suppressing late allergic reactions through the inhibition of 
      proliferation and chemotaxis of inflammatory cells such as eosinophils.
FAU - Lee, Seung-Sin
AU  - Lee SS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University 
      College of Medicine, Seoul, Korea.
FAU - Won, Tae-Bin
AU  - Won TB
FAU - Kim, Jeong-Whun
AU  - Kim JW
FAU - Rhee, Chae-Seo
AU  - Rhee CS
FAU - Lee, Chul-Hee
AU  - Lee CH
FAU - Hong, Seok-Chan
AU  - Hong SC
FAU - Min, Yang-Gi
AU  - Min YG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Glucocorticoids)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology/pathology
MH  - Dexamethasone/*therapeutic use
MH  - Disease Models, Animal
MH  - Eosinophils/pathology
MH  - Female
MH  - Gene Expression/*drug effects
MH  - Glucocorticoids/*therapeutic use
MH  - Immunoglobulin E/metabolism
MH  - Immunohistochemistry
MH  - Leukocyte Count
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa/immunology/metabolism/pathology
MH  - Ovalbumin/toxicity
MH  - RNA, Messenger/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Rhinitis, Allergic, Seasonal/chemically induced/drug therapy/metabolism
MH  - Transforming Growth Factor beta/*genetics/metabolism
EDAT- 2007/09/01 09:00
MHDA- 2007/09/21 09:00
CRDT- 2007/09/01 09:00
PHST- 2007/09/01 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/09/01 09:00 [entrez]
AID - 00005537-200708000-00002 [pii]
AID - 10.1097/MLG.0b013e318064e84d [doi]
PST - ppublish
SO  - Laryngoscope. 2007 Aug;117(8):1323-8. doi: 10.1097/MLG.0b013e318064e84d.