PMID- 17762517
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20090707
IS  - 0955-8810 (Print)
IS  - 0955-8810 (Linking)
VI  - 18
IP  - 5-6
DP  - 2007 Sep
TI  - Investigating the neurobiology of music: brain-derived neurotrophic factor 
      modulation in the hippocampus of young adult mice.
PG  - 491-6
AB  - It has been shown that music might be able to improve mood state in people 
      affected by psychiatric disorders, ameliorate cognitive deficits in people with 
      dementia and increase motor coordination in Parkinson patients. Robust 
      experimental evidence explaining the central effects of music, however, is 
      missing. This study was designed to investigate the effect of music on brain 
      neurotrophin production and behavior in the mouse. We exposed young adult mice to 
      music with a slow rhythm (6 h/day; mild sound pressure levels, between 50 and 60 
      db) for 21 consecutive days. At the end of the treatment, mice were tested for 
      passive avoidance learning and then killed for analysis of brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor with enzyme-linked 
      immunosorbent assay (ELISA) in selected brain regions. We found that 
      music-exposed mice showed increased BDNF, but not nerve growth factor in the 
      hippocampus. Furthermore, we observed that music exposure significantly enhanced 
      learning performance, as measured by the passive avoidance test. Our results 
      demonstrate that exposure to music can modulate the activity of the hippocampus 
      by influencing BDNF production. Our findings also suggest that music exposure 
      might be of help in several central nervous system pathologies.
FAU - Angelucci, Francesco
AU  - Angelucci F
AD  - Fondazione Don C. Gnocchi, Catholic University, Largo Gemelli, Rome, Italy. 
      angeluccifrancesco@rm.unicatt.it
FAU - Fiore, Marco
AU  - Fiore M
FAU - Ricci, Enzo
AU  - Ricci E
FAU - Padua, Luca
AU  - Padua L
FAU - Sabino, Andrea
AU  - Sabino A
FAU - Tonali, Pietro Attilio
AU  - Tonali PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Behavior, Animal/*physiology
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*metabolism/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Music
MH  - Nerve Growth Factor/metabolism/physiology
EDAT- 2007/09/01 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/09/01 09:00
PHST- 2007/09/01 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/09/01 09:00 [entrez]
AID - 00008877-200709000-00016 [pii]
AID - 10.1097/FBP.0b013e3282d28f50 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2007 Sep;18(5-6):491-6. doi: 10.1097/FBP.0b013e3282d28f50.