PMID- 17762611
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20070831
IS  - 1040-8711 (Print)
IS  - 1040-8711 (Linking)
VI  - 19
IP  - 5
DP  - 2007 Sep
TI  - Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments.
PG  - 457-62
AB  - PURPOSE OF REVIEW: This review summarizes the current knowledge about hypoxia and 
      hypoxia-inducible factor-1 (HIF-1) for chondrocyte survival, energy generation 
      and matrix synthesis of articular chondrocytes during cartilage homeostasis and 
      disease. RECENT FINDINGS: In recent years increasing evidence of a pivotal role 
      of hypoxia and the transcription factor HIF-1alpha in cartilaginous tissues has 
      been published. Growth plates with functionally inactivated hypoxia-inducible 
      factor-1alpha display great defects in their central areas caused by massive cell 
      death. This very important observation indicates that hypoxia-inducible 
      factor-1alpha is absolutely necessary for chondrocytes to survive extremely low 
      oxygen tensions. Furthermore, hypoxia-inducible factor-1alpha has been shown to 
      have very important functions for the regulation of glucose transport, anaerobic 
      energy generation and matrix synthesis by articular chondrocytes. Besides 
      hypoxia, other factors such as proinflammatory mediators and mechanical load have 
      been shown to increase hypoxia-inducible factor-1alpha activity in articular 
      chondrocytes. All these factors are known to be involved in the pathogenesis of 
      osteoarthritis. Thus, a dependence of osteoarthritis chondrocytes on 
      hypoxia-inducible factor-1alpha to survive and function properly is a reasonable 
      assumption. SUMMARY: Low oxygen tensions and hypoxia-inducible factor-1alpha are 
      important factors in articular chondrocyte behaviour during cartilage homeostasis 
      and osteoarthritis. Hypoxia-inducible factor-1alpha is a highly conserved 
      transcription factor that has key functions in controlling energy generation, 
      cell survival and matrix synthesis by articular and growth-plate chondrocytes.
FAU - Pfander, David
AU  - Pfander D
AD  - Department of Orthopaedic Rehabilitation, Medical Park Bad Rodach, Bad Rodach, 
      Germany. dpfander@t-online.de
FAU - Gelse, Kolja
AU  - Gelse K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Animals
MH  - Cartilage/metabolism
MH  - *Cell Hypoxia
MH  - *Cell Survival
MH  - Chondrocytes/*metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Mice
MH  - Osteoarthritis/*physiopathology
MH  - Rabbits
MH  - Synovial Membrane/metabolism
RF  - 56
EDAT- 2007/09/01 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/01 09:00
PHST- 2007/09/01 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/01 09:00 [entrez]
AID - 00002281-200709000-00011 [pii]
AID - 10.1097/BOR.0b013e3282ba5693 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2007 Sep;19(5):457-62. doi: 10.1097/BOR.0b013e3282ba5693.