PMID- 17764583
OWN - NLM
STAT- MEDLINE
DCOM- 20080403
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 9
IP  - 4
DP  - 2007
TI  - Activating and inhibitory Fc gamma receptors in rheumatoid arthritis: from 
      treatment to targeted therapies.
PG  - 106
AB  - Fc gamma receptors (Fc gammaRs) bind the constant Fc region of IgG molecules. 
      IgG/antigen-containing immune complexes elicit a variety of effector functions in 
      cells that express activating Fc gammaRs. Because activating Fc gammaRs are 
      present on cells from the innate immune system, such as dendritic cells, 
      monocytes/macrophages and granulocytes, these IgG receptors form a crucial link 
      between the innate and the acquired immune systems. Recently, the ability to 
      detect the inhibitory Fc gammaRIIb on cells has indicated an imbalance between 
      activating and inhibitory Fc gammaRs in rheumatoid arthritis. This progress 
      offers an opportunity to study modulation of Fc gammaR balance and could 
      stimulate development of Fc gammaR-directed immunotherapy.
FAU - van Roon, Joel A G
AU  - van Roon JA
LA  - eng
PT  - Comment
PT  - Editorial
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (Receptors, IgG)
SB  - IM
CON - Arthritis Res Ther. 2007;9(3):R51. PMID: 17521421
MH  - Arthritis, Rheumatoid/drug therapy/immunology/*metabolism
MH  - Dendritic Cells/immunology/metabolism
MH  - Drug Delivery Systems
MH  - Granulocytes/immunology/metabolism
MH  - Humans
MH  - Immunotherapy
MH  - Macrophages/immunology/metabolism
MH  - Monocytes/immunology/metabolism
MH  - Receptors, IgG/immunology/*metabolism
PMC - PMC2206374
EDAT- 2007/09/04 09:00
MHDA- 2008/04/04 09:00
PMCR- 2007/08/20
CRDT- 2007/09/04 09:00
PHST- 2007/09/04 09:00 [pubmed]
PHST- 2008/04/04 09:00 [medline]
PHST- 2007/09/04 09:00 [entrez]
PHST- 2007/08/20 00:00 [pmc-release]
AID - ar2224 [pii]
AID - 10.1186/ar2224 [doi]
PST - ppublish
SO  - Arthritis Res Ther. 2007;9(4):106. doi: 10.1186/ar2224.