PMID- 17766645
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20131121
IS  - 1479-6813 (Electronic)
IS  - 0952-5041 (Linking)
VI  - 39
IP  - 3
DP  - 2007 Sep
TI  - Expression of neuromedin B in adipose tissue and its regulation by changes in 
      energy balance.
PG  - 199-210
AB  - Bombesin is one of the most powerful substances showing anorexic effects in the 
      hypothalamus (Moody TW & Merali Z 2004 Bombesin-like peptides and associated 
      receptors within the brain: distribution and behavioral implications. Peptides 25 
      511-520). In mammals, neuromedin B (NMB) is one member of a family of 
      bombesin-like peptides, which have been shown to reduce food intake when 
      administered systemically. Using Taqman real-time PCR with specific primers, we 
      report the expression of NMB mRNA in both human and rodent adipose tissue. 
      Expression of NMB in rodent epididymal adipose tissue was higher than in other 
      tissues studied. Expression of NMB in adipose tissue appears to be regulated by 
      changes in energy balance and leptin. It is decreased fourfold in the epididymal 
      fat depot of ob/ob mice when compared with the same fat depot in lean mice. It is 
      further decreased with the intra-peritoneally (i.p.) administration of leptin in 
      both lean and obese ob/ob mice. This may relate to its function in food intake 
      regulation or to changes in energy expenditure. We demonstrate that NMB 
      expression in rodent adipose tissue is decreased in cold exposed animals. 
      However, when we investigated the effects of NMB on resting metabolic rate by 
      i.p. injection, there was no effect on oxygen consumption, RQ or physical 
      activity when compared with saline-treated controls. In conclusion, NMB is 
      expressed in both human and rodent adipose tissue and appears to be regulated by 
      changes in energy balance. Given its anorexic effects centrally, it may form part 
      of a new adipose tissue--hypothalamic axis regulating food intake.
FAU - Hoggard, N
AU  - Hoggard N
AD  - Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity 
      (ACERO), Bucksburn, Aberdeen AB21 9SB, UK. nh@rowett.ac.uk
FAU - Bashir, S
AU  - Bashir S
FAU - Cruickshank, M
AU  - Cruickshank M
FAU - Miller, J D B
AU  - Miller JD
FAU - Speakman, J R
AU  - Speakman JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (RNA, Messenger)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 86933-75-7 (Neurokinin B)
RN  - 87096-84-2 (neuromedin B)
RN  - PX9AZU7QPK (Bombesin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/cytology/metabolism
MH  - Adipose Tissue/cytology/*metabolism
MH  - Adult
MH  - Animals
MH  - Body Temperature Regulation
MH  - Bombesin/metabolism
MH  - Cells, Cultured
MH  - Cold Temperature
MH  - *Energy Metabolism
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Leptin/administration & dosage/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Neurokinin B/*analogs & derivatives/genetics/metabolism
MH  - Oxygen Consumption
MH  - RNA, Messenger/metabolism
MH  - Thyroxine/metabolism
MH  - Triiodothyronine/metabolism
EDAT- 2007/09/04 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/09/04 09:00
PHST- 2007/09/04 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/09/04 09:00 [entrez]
AID - 39/3/199 [pii]
AID - 10.1677/JME-07-0071 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 2007 Sep;39(3):199-210. doi: 10.1677/JME-07-0071.