PMID- 17767062
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20190816
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 32
IP  - 4
DP  - 2007 Aug
TI  - [Effect of chemokine interleukin-8, monocyte chemoattractant protein-1 and 
      macrophage inflammatory protein-1 on the angiogenesis of non-small cell lung 
      cancer].
PG  - 665-70
AB  - OBJECTIVE: To detect the expressions of chemokines interleukin-8 (IL-8), monocyte 
      chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 (MIP-1) 
      mRNA in non-small cell lung cancer (NSCLC) tissues, to analyze their relationship 
      with microvessel counts (MVC), and their significance in clinic pathologic 
      features of NSCLC. METHODS: In situ hybridization was used to measure the 
      expressions of chemokine IL-8, MCP-1, and MIP-1 mRNA in 40 NSCLC tissues and 10 
      normal pulmonary tissues, and immunohistochemical staining was carried out to 
      measure the MVC in the above tissues. RESULTS: The positive ratios of IL-8, 
      MCP-1, and MIP-1 mRNA in the 40 NSCLC tissues were apparently higher than those 
      in the 10 normal contrast tissues and the difference was statistically 
      significant. The numbers varied accordingly with the different clinic pathologic 
      features of NSCLC, showing that Group T(3) > Group T(2) or Group T(1), Group III 
      stage> Group II stage> Group I stage Group lymph node and remote transferred > 
      Group non-transferred, and Group of survival time no more than 3 years > Group of 
      survival time more than 3 years. The positive expressions among IL-8, MCP-1,and 
      MIP-1 mRNA and between these and the MVC all had mutually positive correlation. 
      CONCLUSION: Chemokine IL-8, MIP-1, and MIP-1 in NSCLC tissues might cooperate 
      with one another to promote the tumor angiogenesis and affect the progression, 
      metastasis and prognosis of the tumor.
FAU - Zou, Wen
AU  - Zou W
AD  - Department of Oncology, Second Xiangya Hospital, Central South University, 
      Changsha 410011, China. zouwen29w@126.com
FAU - Hu, Tie-Hui
AU  - Hu TH
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*blood supply/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-8/*metabolism
MH  - Lung Neoplasms/*blood supply/metabolism
MH  - Macrophage Inflammatory Proteins/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Neovascularization, Pathologic
MH  - Prognosis
EDAT- 2007/09/04 09:00
MHDA- 2014/03/13 06:00
CRDT- 2007/09/04 09:00
PHST- 2007/09/04 09:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
PHST- 2007/09/04 09:00 [entrez]
AID - 1672-7347(2007)04-0665-06 [pii]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):665-70.