PMID- 17767551
OWN - NLM
STAT- MEDLINE
DCOM- 20071127
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 4
DP  - 2007 Oct
TI  - HLA class I and class II frequencies in patients with sarcoidosis from Croatia: 
      role of HLA-B8, -DRB1*0301, and -DQB1*0201 haplotype in clinical variations of 
      the disease.
PG  - 301-6
AB  - Sarcoidosis is an immune-mediated, multiorgan, granulomatous disease triggered by 
      a combination of environmental and genetic factors. Numerous studies have 
      reported about an association of human leukocyte antigen (HLA) alleles with 
      sarcoidosis, with variation of alleles in different ethnic groups. Therefore, we 
      investigated 142 Croatian sarcoidosis patients treated at the University Hospital 
      for Lung Diseases Jordanovac, Zagreb, Croatia. Diagnosis was based on the 
      presence of typical clinical features, chest X-ray findings and biopsy evidence 
      of granuloma. Patients and control subjects (n = 190) were typed for HLA class I 
      antigens by serology, while for HLA class II, they were tested by the polymerase 
      chain reaction-sequence specific primers (PCR-SSP) method. Results indicated that 
      HLA-B8, -DRB1*0301, and -DQB1*0201 positive patients have a significantly higher 
      risk of acute onset of the disease (AOD), radiological stage I erythema nodosum 
      (EN), Lofgren's syndrome, no-medicament therapy, and pulmonary sarcoidosis. On 
      the other hand, the group of non-treated patients (corticosteroids and/or 
      immunosuppressive) showed a significantly lower presence of HLA-B15 antigen in 
      comparison to controls and treated patients (P = 0.0490 and P = 0.0379, 
      respectively) and for DRB1*04 specificity (P = 0.0078 and P = 0.0065, 
      respectively). In the group of patients with AOD, those who were positive for 
      DRB1*16 specificity have a statistically significant chance to develop EN, as 
      opposed to those who are positive for DRB1*15 specificity.
FAU - Grubic, Z
AU  - Grubic Z
AD  - Tissue Typing Centre, University Hospital Centre Zagreb, Kispaticeva 12, 10000 
      Zagreb, Croatia. zgrubic@kbc-zagreb.hr
FAU - Zunec, R
AU  - Zunec R
FAU - Peros-Golubicic, T
AU  - Peros-Golubicic T
FAU - Tekavec-Trkanjec, J
AU  - Tekavec-Trkanjec J
FAU - Martinez, N
AU  - Martinez N
FAU - Alilovic, M
AU  - Alilovic M
FAU - Smojver-Jezek, S
AU  - Smojver-Jezek S
FAU - Kerhin-Brkljacic, V
AU  - Kerhin-Brkljacic V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Croatia
MH  - Female
MH  - HLA-B8 Antigen/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics/metabolism
MH  - Histocompatibility Antigens Class II/*genetics/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis, Pulmonary/*genetics/physiopathology
EDAT- 2007/09/05 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/05 09:00
PHST- 2007/09/05 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/05 09:00 [entrez]
AID - TAN904 [pii]
AID - 10.1111/j.1399-0039.2007.00904.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Oct;70(4):301-6. doi: 10.1111/j.1399-0039.2007.00904.x.