PMID- 17767552
OWN - NLM
STAT- MEDLINE
DCOM- 20071127
LR  - 20231213
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 4
DP  - 2007 Oct
TI  - Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with 
      Behcet's disease.
PG  - 307-13
AB  - Inhibitory CD94/NKG2A and activating CD94/NKG2C receptors are expressed on 
      natural killer, CD4, and CD8 T cells and recognize human leukocyte antigen 
      (HLA)-E, resulting in the modulation of cytotoxic activity and cytokine 
      production. An imbalance in cytotoxic activity and cytokine production has been 
      implicated in Behcet's disease (BD). The results of this study showed that the 
      NKG2A c.-4258*C, c.338-90*G, and CD94 c.-134*T alleles (P= 0.015, OR = 0.8; P < 
      0.0001, OR = 0.5; and P= 0.034, OR = 0.8, respectively) were associated with 
      decreased risk and that NKG2A c.284-67_-62del, c.1077*C, and the activating 
      receptor, NKG2C c.305*T were not associated with 345 patients with BD. But a 
      significant difference in NKG2C c.305*T was detected among BD patients with 
      ocular lesions and arthritis (P < 0.0001, OR = 2.1 and P= 0.0001, OR = 1.8, 
      respectively). We already showed in our previous research that HLA-E*0101 also 
      appears to contribute to a reduction in risk through the inhibitory 
      CD94/NKG2A-mediated immune response. This result led us to the analyses of the 
      combined risk of the HLA-E and the NKG2A for BD. Individuals harboring 
      HLA-E*0101, NKG2A c.-4258*C, and c.338-90*G evidenced a reduced risk of BD 
      compared with healthy controls (21.1% vs 40.1%, P < 0.0001, OR = 0.4). By way of 
      contrast, individuals without the HLA-E*0101, NKG2A c.-4258*C, and c.338-90*G 
      alleles evidenced a twofold increased risk of BD (P= 0.014, OR = 2.0). 
      Individuals without HLA-E*0101, NKG2A c.-4258*G/*G, and c.338-90*G evidenced a 
      4.8-fold increase in BD risk (P= 0.0002, OR = 4.8). Although the effects of these 
      single nucleotide polymorphisms (SNPs) remain unclear, our results indicate that 
      the SNPs of the inhibitory receptor CD94/NKG2A and its haplotypes, as well as its 
      ligand HLA-E, are associated with BD immune systems.
FAU - Seo, J
AU  - Seo J
AD  - Department of Biology and Institute of Basic Science, Sungshin Women's 
      University, 249-1 3-ga, Dongseon-dong, Sungbuk-ku, Seoul 136-742, Korea.
FAU - Park, J S
AU  - Park JS
FAU - Nam, J H
AU  - Nam JH
FAU - Bang, D
AU  - Bang D
FAU - Sohn, S
AU  - Sohn S
FAU - Lee, E S
AU  - Lee ES
FAU - Park, K S
AU  - Park KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily D)
SB  - IM
MH  - Alleles
MH  - Behcet Syndrome/*genetics/immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology/metabolism
MH  - Histocompatibility Antigens Class I/*genetics/immunology/metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Ligands
MH  - Male
MH  - NK Cell Lectin-Like Receptor Subfamily D/*genetics/immunology/metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - HLA-E Antigens
EDAT- 2007/09/05 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/05 09:00
PHST- 2007/09/05 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/05 09:00 [entrez]
AID - TAN907 [pii]
AID - 10.1111/j.1399-0039.2007.00907.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Oct;70(4):307-13. doi: 10.1111/j.1399-0039.2007.00907.x.