PMID- 17767554
OWN - NLM
STAT- MEDLINE
DCOM- 20071127
LR  - 20070904
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 4
DP  - 2007 Oct
TI  - Characterization of a new HLA-B allele, HLA-B*5312, and re-evaluation of the 
      published sequences of the untranslated regions of HLA-B*35 and HLA-B*53.
PG  - 319-23
AB  - We report a novel human leukocyte antigen (HLA)-B allele, HLA-B*5312. Compared 
      with HLA-B*530101, there is one silent substitution at nucleotide 438 and two 
      non-synonymous substitutions at nucleotides 431 and 440, causing a change of the 
      amino acid sequence (Asn-->Ser at codon 77 and Ile-->Thr at codon 80, 
      respectively) within the Bw4 epitope. In contrast to the published sequences 
      (IMGT/HLA Database, version 2.16.0, January 2007), we found that HLA-B*530101 had 
      a C instead of a T at nucleotide -221, whereas HLA-B*350101 had a C instead of an 
      A at nucleotide 2992. According to our sequencing results, HLA-B*5312 resembles 
      HLA-B*350101 regarding its sequence of the untranslated regions. HLA-B*5312 may 
      have been the result of a double crossing over event during which HLA-B*350101 
      adopted a Bw4 motif.
FAU - Heinold, A
AU  - Heinold A
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany. 
      hien.tran@med.uni-heidelberg.de
FAU - Bauer, M
AU  - Bauer M
FAU - Scherer, S
AU  - Scherer S
FAU - Opelz, G
AU  - Opelz G
FAU - Tran, T H
AU  - Tran TH
LA  - eng
SI  - GENBANK/AM292927
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (Untranslated Regions)
SB  - IM
MH  - *Alleles
MH  - Base Sequence
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Untranslated Regions
EDAT- 2007/09/05 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/05 09:00
PHST- 2007/09/05 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/05 09:00 [entrez]
AID - TAN900 [pii]
AID - 10.1111/j.1399-0039.2007.00900.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Oct;70(4):319-23. doi: 10.1111/j.1399-0039.2007.00900.x.