PMID- 17767555
OWN - NLM
STAT- MEDLINE
DCOM- 20071127
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 4
DP  - 2007 Oct
TI  - Genetic analyses of celiac disease in a Spanish population confirm association 
      with CELIAC3 but not with CELIAC4.
PG  - 324-9
AB  - Genetic predisposition to celiac disease (CD) is determined primarily by the 
      human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci 
      are involved in disease susceptibility. First, we have analysed a large series of 
      CD patients from the Spanish Mediterranean region who had previously been 
      characterised for the HLA complex. We have investigated how relevant regions 
      contribute to CD susceptibility: CELIAC3 (CD28/CTLA4/ICOS region on 2q33) and 
      CELIAC4 (19p13) as well as the tumour necrosis factor alpha (TNF-alpha) and the 
      linfotoxin loci by case-control and association analyses. We highlight the 
      association with the +49*A allele of cytotoxic T-lymphocyte-associated antigen 4 
      locus (P = 0.01), and the -308*A of TNF-alpha locus (P = 0.0008) in DQ2 
      individuals, although an independent role for TNF-alpha as risk factor has not 
      been proven. Moreover, we do not confirm the association with the CELIAC4 region 
      polymorphisms described in other populations.
FAU - Capilla, A
AU  - Capilla A
AD  - Laboratory of Genetics and Molecular Medicine, Instituto de Biomedicina, Consejo 
      Superior de Investigaciones Cientificas, c/Jaume Roig 11, 46010 Valencia, Spain.
FAU - Donat, E
AU  - Donat E
FAU - Planelles, D
AU  - Planelles D
FAU - Espinos, C
AU  - Espinos C
FAU - Ribes-Koninckx, C
AU  - Ribes-Koninckx C
FAU - Palau, F
AU  - Palau F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (myosin IXB)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Alleles
MH  - Antigens, CD/*genetics
MH  - Antigens, Differentiation/*genetics
MH  - CTLA-4 Antigen
MH  - Case-Control Studies
MH  - Celiac Disease/*genetics/metabolism
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Myosins/*genetics
MH  - Polymorphism, Genetic
MH  - Spain
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
EDAT- 2007/09/05 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/05 09:00
PHST- 2007/09/05 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/05 09:00 [entrez]
AID - TAN899 [pii]
AID - 10.1111/j.1399-0039.2007.00899.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Oct;70(4):324-9. doi: 10.1111/j.1399-0039.2007.00899.x.