PMID- 17767807
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20131121
IS  - 0161-6412 (Print)
IS  - 0161-6412 (Linking)
VI  - 30
IP  - 1
DP  - 2008 Feb
TI  - Pergolide protects CA1 neurons from apoptosis in a gerbil model of global 
      cerebral ischemia.
PG  - 92-8
AB  - OBJECTIVE: To investigate the effects of dopamine (DA) receptor agonists and 
      antagonists on neuronal apoptosis in hippocampal CA1 region after forebrain 
      ischemia/reperfusion (I/R) injury in gerbils. METHODS: Gerbil forebrain ischemia 
      was induced by occluding bilateral carotid arteries for 5 minutes. The open field 
      test, hematoxylin-eosin staining and in situ terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) methods were used 1, 3 and 7 
      days after reperfusion. Western blot was used to examine the phosphorylation of 
      c-Jun. RESULTS: Pergolide could significantly reduce the habituation impairments 
      of ischemic gerbils, increase the number of normal neurons and reduce the number 
      of apoptotic neurons in hippocampal CA1 region after reperfusion. SKF38393, 
      SCH23390 and spiperone had no effects on these changes in this transient I/R 
      injury model. Furthermore, pergolide can significantly reduce the phosphorylation 
      of c-Jun induced by transient forebrain ischemia.
FAU - Zong, Xue-Mei
AU  - Zong XM
AD  - Center of Emergency, Affiliated Hospital of Xuzhou Medical College, Xuzhou 
      221002, China.
FAU - Sun, Ya-Feng
AU  - Sun YF
FAU - Pei, Dong-Sheng
AU  - Pei DS
FAU - Zeng, Yin-Ming
AU  - Zeng YM
FAU - Xu, Tie
AU  - Xu T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Dopamine Agonists)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 24MJ822NZ9 (Pergolide)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Behavior, Animal/drug effects
MH  - *Brain Ischemia/drug therapy/pathology/physiopathology
MH  - Disease Models, Animal
MH  - Dopamine Agonists/*therapeutic use
MH  - Exploratory Behavior/drug effects
MH  - Gerbillinae
MH  - Hippocampus/*pathology
MH  - In Situ Nick-End Labeling/methods
MH  - Male
MH  - Neurons/*drug effects
MH  - Pergolide/*therapeutic use
MH  - Proto-Oncogene Proteins c-jun/metabolism
MH  - Time Factors
EDAT- 2007/09/05 09:00
MHDA- 2008/06/21 09:00
CRDT- 2007/09/05 09:00
PHST- 2007/09/05 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2007/09/05 09:00 [entrez]
AID - 10.1179/016164107X228688 [doi]
PST - ppublish
SO  - Neurol Res. 2008 Feb;30(1):92-8. doi: 10.1179/016164107X228688.