PMID- 1777846
OWN - NLM
STAT- MEDLINE
DCOM- 19920310
LR  - 20190720
IS  - 0008-4212 (Print)
IS  - 0008-4212 (Linking)
VI  - 69
IP  - 10
DP  - 1991 Oct
TI  - Interleukin-6 is a centrally acting endogenous pyrogen in the rat.
PG  - 1465-9
AB  - Intracerebroventricular (i.c.v.) injection of human recombinant interleukin-6 
      (IL-6; 20-100 ng) caused significant increases in colonic temperature and resting 
      oxygen consumption (VO2) in conscious rats. These effects were prevented by 
      pretreatment with a cyclooxygenase inhibitor (flurbiprofen, 1 mg/kg, i.p.) or a 
      corticotrophin-releasing factor antagonist (alpha-helical CRF9-41, 25 micrograms, 
      i.c.v.). Higher doses of IL-6 (i.c.v.) caused only small changes in VO2 and 
      temperature, and very high doses given intravenously (i.v.) (4 micrograms/kg) 
      were required to stimulate these parameters. Central injection of anti-rat IL-6 
      antibody inhibited the effects of interleukin-1 beta (i.c.v.) or endotoxin 
      injection (i.p.) on colonic temperature and VO2 in conscious rats. These data 
      indicate that IL-6 is an important endogenous pyrogen that acts within the 
      central nervous system.
FAU - Rothwell, N J
AU  - Rothwell NJ
AD  - Department of Physiology, University of Manchester, U.K.
FAU - Busbridge, N J
AU  - Busbridge NJ
FAU - Lefeuvre, R A
AU  - Lefeuvre RA
FAU - Hardwick, A J
AU  - Hardwick AJ
FAU - Gauldie, J
AU  - Gauldie J
FAU - Hopkins, S J
AU  - Hopkins SJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Interleukin-6)
RN  - 0 (Pyrogens)
RN  - 0 (Recombinant Proteins)
RN  - 5GRO578KLP (Flurbiprofen)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Fever/chemically induced
MH  - Flurbiprofen/pharmacology
MH  - Interleukin-6/immunology/*pharmacology
MH  - Male
MH  - Oxygen Consumption/drug effects
MH  - Pyrogens/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Recombinant Proteins/pharmacology
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1139/y91-219 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 1991 Oct;69(10):1465-9. doi: 10.1139/y91-219.