PMID- 17785583
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 110
IP  - 13
DP  - 2007 Dec 15
TI  - High-resolution donor-recipient HLA matching contributes to the success of 
      unrelated donor marrow transplantation.
PG  - 4576-83
AB  - The relative importance of various human leukocyte antigen (HLA) loci and the 
      resolution level at which they are matched has not been fully defined for 
      unrelated donor transplantation. To address this question, National Marrow Donor 
      Program data from 3857 transplantations performed from 1988 to 2003 in the United 
      States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, 
      -DRB1, -DQB1, -DQA1, -DPB1, and -DPA1 alleles. High-resolution DNA matching for 
      HLA-A, -B, -C, and -DRB1 (8/8 match) was the minimum level of matching associated 
      with the highest survival. A single mismatch detected by low- or high-resolution 
      DNA testing at HLA-A, -B, -C or -DRB1 (7/8 match) was associated with higher 
      mortality (relative risk, 1.25; 95% CI, 1.13-1.38; P < .001) and 1-year survival 
      of 43% compared with 52% for 8/8 matched pairs. Single mismatches at HLA-B or 
      HLA-C appear better tolerated than mismatches at HLA-A or HLA-DRB1. Mismatching 
      at 2 or more loci compounded the risk. Mismatching at HLA-DP or -DQ loci and 
      donor factors other than HLA type were not associated with survival. In 
      multivariate modeling, patient age, race, disease stage, and cytomegalovirus 
      status were as predictive of survival as donor HLA matching. High-resolution DNA 
      matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of 
      survival.
FAU - Lee, Stephanie J
AU  - Lee SJ
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 
      98109, USA. sjlee@fhcrc.org
FAU - Klein, John
AU  - Klein J
FAU - Haagenson, Michael
AU  - Haagenson M
FAU - Baxter-Lowe, Lee Ann
AU  - Baxter-Lowe LA
FAU - Confer, Dennis L
AU  - Confer DL
FAU - Eapen, Mary
AU  - Eapen M
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
FAU - Flomenberg, Neal
AU  - Flomenberg N
FAU - Horowitz, Mary
AU  - Horowitz M
FAU - Hurley, Carolyn K
AU  - Hurley CK
FAU - Noreen, Harriet
AU  - Noreen H
FAU - Oudshoorn, Machteld
AU  - Oudshoorn M
FAU - Petersdorf, Effie
AU  - Petersdorf E
FAU - Setterholm, Michelle
AU  - Setterholm M
FAU - Spellman, Stephen
AU  - Spellman S
FAU - Weisdorf, Daniel
AU  - Weisdorf D
FAU - Williams, Thomas M
AU  - Williams TM
FAU - Anasetti, Claudio
AU  - Anasetti C
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070904
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Bone Marrow Transplantation/methods/mortality/*standards
MH  - Child
MH  - Child, Preschool
MH  - DNA
MH  - HLA Antigens/*genetics
MH  - *Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Infant
MH  - Middle Aged
MH  - Registries
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Tissue Donors
MH  - Treatment Outcome
EDAT- 2007/09/06 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/09/06 09:00
PHST- 2007/09/06 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/09/06 09:00 [entrez]
AID - S0006-4971(20)52909-1 [pii]
AID - 10.1182/blood-2007-06-097386 [doi]
PST - ppublish
SO  - Blood. 2007 Dec 15;110(13):4576-83. doi: 10.1182/blood-2007-06-097386. Epub 2007 
      Sep 4.