PMID- 17803220
OWN - NLM
STAT- MEDLINE
DCOM- 20080404
LR  - 20080121
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 86
IP  - 1
DP  - 2008 Jan
TI  - Cross-talk between the epidermal growth factor-like repeats/fibronectin 6-8 
      repeats domains of Tenascin-R and microglia modulates neural stem/progenitor cell 
      proliferation and differentiation.
PG  - 27-34
AB  - Mounting evidence has demonstrated that the microenvironment of stem/progenitor 
      cells plays an important role in their proliferation and commitment to their 
      fate. However, it remains unclear how all elements, such as astrocytes, 
      microglia, extracellular matrix molecules, soluble factors, and their cross-talk 
      interactions in the microenvironments, affect neural stem/progenitor cell fate. 
      This work explored the influences of cross-talk between Tenascin-R (TN-R) and 
      microglia on neural stem/progenitor cell proliferation and differentiation. Our 
      results show that microglia triggered by TN-R distinct domains EGF-like repeats 
      (EGFL) and fibronectin 6-8 repeats (FN6-8) significantly enhanced the 
      proliferation of neural stem/progenitor cells and also obviously induced the 
      differentiation into neurons but not oligodendrocytes. Neurite processes of 
      neurons generated from neural progenitor cells were promoted by both EGFL and 
      FN6-8 domains-activated microglia. Microglia triggered by EGFL and FN6-8 secreted 
      brain-derived neurotrophic factor (BDNF) and transforming growth factor-beta 
      (TGF-beta); interestingly, FN6-8 could activate microglia to secrete nerve growth 
      factor in addition to BDNF and TGF-beta, but EGFL domain could not. All these 
      data implied that the cross-talk between TN-R distinct domains EGFL/FN6-8 and 
      microglia promoted neural stem/progenitor cell proliferation and induced their 
      differentiation into neurons.
FAU - Liao, Hong
AU  - Liao H
AD  - Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical 
      University, Nanjing, China. gcrlh@yahoo.com.cn
FAU - Huang, Wenhui
AU  - Huang W
FAU - Niu, Rui
AU  - Niu R
FAU - Sun, Lixin
AU  - Sun L
FAU - Zhang, Luyong
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Fibronectins)
RN  - 0 (Tenascin)
RN  - 147604-77-1 (tenascin R)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/drug effects/*physiology
MH  - *Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology
MH  - Culture Media, Conditioned/pharmacology
MH  - Embryo, Mammalian
MH  - Embryonic Stem Cells/*physiology
MH  - Epidermal Growth Factor/*metabolism
MH  - Fibronectins/metabolism
MH  - Microglia/chemistry/*physiology
MH  - Neurons/drug effects/*physiology
MH  - Protein Structure, Tertiary/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tenascin/*metabolism
EDAT- 2007/09/07 09:00
MHDA- 2008/04/05 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2008/04/05 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - 10.1002/jnr.21454 [doi]
PST - ppublish
SO  - J Neurosci Res. 2008 Jan;86(1):27-34. doi: 10.1002/jnr.21454.