PMID- 17804189
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20220316
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 25
IP  - 6
DP  - 2007 Oct
TI  - Age-related changes in BDNF protein levels in human serum: differences between 
      autism cases and normal controls.
PG  - 367-72
AB  - Accumulating evidence suggests the possible association between the 
      concentrations of serum brain-derived neurotrophic factor (BDNF) and psychiatric 
      disease with impaired brain development. Yet the reasons remain unclear. We 
      therefore investigated the characteristics of serum BDNF as well as its 
      age-related changes in healthy controls in comparison to autism cases. BDNF was 
      gradually released from platelets at 4 degrees C, reached a maximal concentration 
      after around 24 h, and remained stable until 42 h. At room temperature, BDNF was 
      found to be immediately degraded. Circadian changes, but not seasonal changes, 
      were found in serum levels of BDNF existing as the mature form with a molecular 
      mass of 14 kDa. In healthy controls, the serum BDNF concentration increased over 
      the first several years, then slightly decreased after reaching the adult level. 
      There were no sex differences between males and females. In the autism cases, 
      mean levels were significantly lower in children 0-9 years old compared to 
      teenagers or adults, or to age-matched healthy controls, indicating a delayed 
      BDNF increase with development. In a separate study of adult rats, a circadian 
      change in serum BDNF was found to be similar to that in the cortex, indicating a 
      possible association with cortical functions.
FAU - Katoh-Semba, Ritsuko
AU  - Katoh-Semba R
AD  - Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, 
      Japan. katohsemba@inst-hsc.jp
FAU - Wakako, Rie
AU  - Wakako R
FAU - Komori, Taku
AU  - Komori T
FAU - Shigemi, Hiroko
AU  - Shigemi H
FAU - Miyazaki, Noriko
AU  - Miyazaki N
FAU - Ito, Hironori
AU  - Ito H
FAU - Kumagai, Toshiyuki
AU  - Kumagai T
FAU - Tsuzuki, Masako
AU  - Tsuzuki M
FAU - Shigemi, Kenji
AU  - Shigemi K
FAU - Yoshida, Futoshi
AU  - Yoshida F
FAU - Nakayama, Atsuo
AU  - Nakayama A
LA  - eng
PT  - Journal Article
DEP - 20070801
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aging/*blood
MH  - Animals
MH  - Autistic Disorder/*blood/physiopathology
MH  - Blood Platelets/metabolism
MH  - Brain/*growth & development/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood/chemistry
MH  - Cerebral Cortex/growth & development/metabolism/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Circadian Rhythm/physiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Rats
MH  - Seasons
MH  - Sex Distribution
MH  - Specimen Handling
MH  - Temperature
MH  - Time Factors
MH  - Up-Regulation/physiology
EDAT- 2007/09/07 09:00
MHDA- 2008/02/20 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/05/21 00:00 [received]
PHST- 2007/07/11 00:00 [revised]
PHST- 2007/07/17 00:00 [accepted]
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - S0736-5748(07)00098-6 [pii]
AID - 10.1016/j.ijdevneu.2007.07.002 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2007 Oct;25(6):367-72. doi: 10.1016/j.ijdevneu.2007.07.002. 
      Epub 2007 Aug 1.