PMID- 17804193
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20240109
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 62
IP  - 5
DP  - 2008 Jun
TI  - Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and 
      inflammation in a murine asthma model: role of suppressor of cytokine signaling.
PG  - 289-96
AB  - Ecklonia cava (EC) is a brown alga that evidences radical scavenging activity, 
      bactericidal activity, tyrosinase inhibitory activity, and protease inhibitory 
      activity. However, its anti-allergic effects remain poorly understood. In the 
      current study, we attempted to determine whether pretreatment with EC induces a 
      significant inhibition of asthmatic reactions in a mouse asthma model. Mice 
      sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic 
      reactions, as follows: an increase in the number of eosinophils in 
      bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung 
      around blood vessels and airways, and airway luminal narrowing; the development 
      of airway hyperresponsiveness; the detection of tumor necrosis factor-alpha 
      (TNF-alpha) and Th2 cytokines, including IL-4 and IL-5 in the bronchoalveolar 
      lavage (BAL) fluid; and the detection of allergen-specific immunoglobulin E (IgE) 
      in the serum. However, the administration of EC extract prior to the final airway 
      OVA challenge resulted in a significant inhibition of all asthmatic reactions. We 
      also demonstrated that EC extracts treatment resulted in significant reductions 
      on matrix metalloproteinase-9 (MMP-9) and Suppressor of cytokine signaling-3 
      (SOCS-3) expression and a reduction in the increased eosinophil peroxidase (EPO) 
      activity. The treatment of animals with EC extracts resulted in a significant 
      reduction in the concentrations of the Th2 cytokine (IL-4 and IL-5) in the 
      airways, without any concomitant increase in the concentration of Th1 cytokines. 
      These findings indicate that EC extracts may prove useful as an adjuvant therapy 
      for allergic airway reactions via the inhibition of the Th2 response. 
      Accordingly, this study may provide evidence that EC extract performs a critical 
      function in the amelioration of the pathogenetic process of asthma in mice.
FAU - Kim, Se-Kwon
AU  - Kim SK
AD  - Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, 
      Republic of Korea.
FAU - Lee, Da-Young
AU  - Lee DY
FAU - Jung, Won-Kyo
AU  - Jung WK
FAU - Kim, Ji-Hye
AU  - Kim JH
FAU - Choi, Inhak
AU  - Choi I
FAU - Park, Sae-Gwang
AU  - Park SG
FAU - Seo, Su-Kil
AU  - Seo SK
FAU - Lee, Soo-Woong
AU  - Lee SW
FAU - Lee, Chang Min
AU  - Lee CM
FAU - Yea, Sung Su
AU  - Yea SS
FAU - Choi, Yung Hyun
AU  - Choi YH
FAU - Choi, Il-Whan
AU  - Choi IW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070810
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (Socs3 protein, mouse)
RN  - 0 (Socs5 protein, mouse)
RN  - 0 (Solvents)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.11.1.- (Eosinophil Peroxidase)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/immunology/*therapeutic use
MH  - Asthma/*drug therapy/immunology/metabolism
MH  - Bronchial Hyperreactivity/*drug therapy/immunology/metabolism
MH  - Bronchoalveolar Lavage Fluid/chemistry/immunology
MH  - Bronchoconstrictor Agents/pharmacology
MH  - Cytokines/*metabolism
MH  - Eosinophil Peroxidase/metabolism
MH  - Ethanol
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Matrix Metalloproteinase 3/biosynthesis
MH  - Methacholine Chloride/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Phaeophyceae/*chemistry
MH  - Phytotherapy
MH  - Plant Extracts/therapeutic use
MH  - Solvents
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins/biosynthesis
EDAT- 2007/09/07 09:00
MHDA- 2008/10/31 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/07/02 00:00 [received]
PHST- 2007/07/18 00:00 [accepted]
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - S0753-3322(07)00139-4 [pii]
AID - 10.1016/j.biopha.2007.07.009 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2008 Jun;62(5):289-96. doi: 10.1016/j.biopha.2007.07.009. 
      Epub 2007 Aug 10.