PMID- 17805056
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20180822
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 2
IP  - 9
DP  - 2007 Sep
TI  - HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas.
PG  - 802-7
AB  - BACKGROUND: Outcomes of patients with lung adenocarcinomas can be predicted to 
      some extent from the pathologic stage (p-stage). Although all attempts are made 
      to fully remove cancer lesions, still a number of p-stage I patients without 
      metastatic disease at the time of surgery develop recurrences and die of cancer. 
      It is thus very important to identify p-stage I patients who are at risk of 
      recurrence. METHODS: Previously, using microdissected samples, we identified 
      metastasis-related genes. Using real-time reverse-transcriptase polymerase chain 
      reaction analysis, we investigated the transcriptional levels of the top 
      metastasis-related genes using 96 independent test lung adenocarcinoma samples 
      and investigated their correlations with the prognosis. RESULTS AND CONCLUSIONS: 
      We document evidence that p-stage I patients with HOXB2 up-regulation have a 
      worse prognosis than those with HOXB2 down-regulation (p = 0.0065), whereas the 
      HOXB2 status has no prognostic significance for p-stage II-IV patients. Comparing 
      tumors and corresponding normal lung tissue, we confirmed HOXB2 up-regulated 
      lesions to have much higher HOXB2 expression than the corresponding normal 
      tissue. Confirmation with a larger number of samples is needed, with further 
      research to clarify the molecular functions of HOXB2.
FAU - Inamura, Kentaro
AU  - Inamura K
AD  - Department of Pathology, The Cancer Institute, The Cancer Institute Hospital, 
      Japanese Foundation for Cancer Research, Tokyo, Japan.
FAU - Togashi, Yuki
AU  - Togashi Y
FAU - Okui, Michiyo
AU  - Okui M
FAU - Ninomiya, Hironori
AU  - Ninomiya H
FAU - Hiramatsu, Miyako
AU  - Hiramatsu M
FAU - Satoh, Yukitoshi
AU  - Satoh Y
FAU - Okumura, Sakae
AU  - Okumura S
FAU - Nakagawa, Ken
AU  - Nakagawa K
FAU - Shimoji, Takashi
AU  - Shimoji T
FAU - Noda, Tetsuo
AU  - Noda T
FAU - Ishikawa, Yuichi
AU  - Ishikawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International 
      Association for the Study of Lung Cancer
JID - 101274235
RN  - 0 (HOXB2 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Transcription Factors)
SB  - IM
EIN - J Thorac Oncol. 2008 Jan;3(1):100. Ishikawa, Yuichi [added]
MH  - *Adenocarcinoma/genetics/metabolism/pathology
MH  - Cell Differentiation
MH  - Cell Line, Tumor
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Homeodomain Proteins/*genetics/metabolism
MH  - Humans
MH  - *Lung Neoplasms/genetics/metabolism/pathology
MH  - Male
MH  - Neoplasm Staging
MH  - Nuclear Proteins
MH  - Prognosis
MH  - RNA, Neoplasm/*genetics
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription Factors/*genetics/metabolism
EDAT- 2007/09/07 09:00
MHDA- 2007/09/28 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - S1556-0864(15)30867-4 [pii]
AID - 10.1097/JTO.0b013e3181461987 [doi]
PST - ppublish
SO  - J Thorac Oncol. 2007 Sep;2(9):802-7. doi: 10.1097/JTO.0b013e3181461987.