PMID- 17805088
OWN - NLM
STAT- MEDLINE
DCOM- 20071221
LR  - 20131121
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 39
IP  - 9
DP  - 2007 Sep
TI  - Immunoendocrine response to cycling following ingestion of caffeine and 
      carbohydrate.
PG  - 1554-60
AB  - PURPOSE: This study investigated the effect of caffeine consumed with and without 
      carbohydrate (CHO) on immunoendocrine responses after exercise. METHODS: On four 
      occasions, 12 recreational male cyclists cycled for 2 h at 65% V O2max. Sixty 
      minutes before exercise, participants ingested 6 mg.kg(-1) body mass of caffeine 
      (CAF) or placebo (PLA), then during exercise they consumed a 6% CHO or placebo 
      (PLA) drink, providing CAF/CHO, PLA/CHO, CAF/PLA, and PLA/PLA conditions. 
      RESULTS: f-MLP-stimulated neutrophil oxidative burst responses were significantly 
      higher after exercise on CAF/CHO and PLA/CHO (both P<0.05) than PLA/PLA when 
      expressed as a percentage of baseline value. The response on CAF/PLA tended to be 
      higher than PLA/PLA at this point (P=0.056). No significant differences between 
      CAF/CHO, PLA/CHO, and CAF/PLA were observed after exercise; however, only PLA/CHO 
      showed no significant postexercise decline. Coingestion of CAF/CHO significantly 
      attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after 
      ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient 
      alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts. 
      Plasma cortisol concentration was significantly lower on PLA/CHO than CAF/PLA and 
      PLA/PLA after exercise (P<0.05). Perceived exertion during exercise was 
      significantly lower on CAF/CHO than the other three trials (P<0.05). CONCLUSION: 
      Taken together, this suggests that coingestion of caffeine and CHO has greater 
      influence on immunoendocrine responses than neutrophil functional responses to 
      prolonged exercise.
FAU - Walker, Gary J
AU  - Walker GJ
AD  - School of Sport and Exercise Sciences, Loughborough University, Leicestershire, 
      UK. G.J.Walker2@lboro.ac.uk
FAU - Finlay, Oliver
AU  - Finlay O
FAU - Griffiths, Hannah
AU  - Griffiths H
FAU - Sylvester, James
AU  - Sylvester J
FAU - Williams, Mark
AU  - Williams M
FAU - Bishop, Nicolette C
AU  - Bishop NC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Carbohydrates)
RN  - 0 (Central Nervous System Stimulants)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Adult
MH  - Bicycling/*physiology
MH  - Caffeine/administration & dosage/blood/*pharmacology
MH  - Carbohydrates/administration & dosage/blood/*pharmacology
MH  - Central Nervous System Stimulants/administration & dosage/blood/*pharmacology
MH  - Endocrine System/*drug effects/physiology
MH  - Humans
MH  - Immune System/*drug effects/physiology
MH  - Leukocyte Count
MH  - Male
MH  - Oxygen Consumption/drug effects
MH  - Respiratory Burst/*drug effects/physiology
EDAT- 2007/09/07 09:00
MHDA- 2007/12/22 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2007/12/22 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - 00005768-200709000-00017 [pii]
AID - 10.1249/mss.0b013e3180a74228 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2007 Sep;39(9):1554-60. doi: 10.1249/mss.0b013e3180a74228.