PMID- 17805330
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20130304
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 22
IP  - 1
DP  - 2008 Jan
TI  - Current status of reduced-intensity allogeneic stem cell transplantation using 
      alternative donors.
PG  - 31-41
AB  - The optimal donor for a patient undergoing reduced-intensity stem cell 
      transplantation remains a human leukocyte antigen (HLA)-matched relative. 
      Alternative donors such as matched unrelated donors (MUDs), mismatched related 
      donors (haploidentical), or unrelated umbilical cord blood (UCB) units have 
      emerged as options as well. The most experience thus far has been with MUD 
      donors, mostly attributed to the development of allele-specific DNA-based 
      HLA-typing methods. The biggest drawback remains the significant delay needed to 
      locate a donor. Haploidentical donors exist for almost all patients, and offer 
      the convenience of a living related donor. However, significant rates of 
      graft-versus-host disease (GVHD) and other toxicities continue to complicate such 
      HLA mismatching. UCB is the most recent option for source of stem cells. Frozen 
      cord blood units can be acquired almost immediately and are able to safely 
      traverse 1 or 2-HLA antigen mismatch barriers. The experience with UCB has been 
      limited by the low cell dose, although recent innovations are attempting to 
      overcome this. In this review, we summarize the current experience and knowledge 
      with alternative donors as stem cell sources for reduced-intensity 
      transplantation.
FAU - Chen, Y-B
AU  - Chen YB
AD  - Hematology/Oncology Unit, Division of Bone Marrow Transplantation, Massachusetts 
      General Hospital, Boston, MA 02114, USA.
FAU - Spitzer, T R
AU  - Spitzer TR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070906
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Fetal Blood
MH  - Graft vs Host Disease
MH  - Humans
MH  - Leukemia/*therapy
MH  - *Stem Cell Transplantation
MH  - *Tissue Donors
MH  - Transplantation, Homologous
RF  - 93
EDAT- 2007/09/07 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - 2404932 [pii]
AID - 10.1038/sj.leu.2404932 [doi]
PST - ppublish
SO  - Leukemia. 2008 Jan;22(1):31-41. doi: 10.1038/sj.leu.2404932. Epub 2007 Sep 6.