PMID- 17805458
OWN - NLM
STAT- MEDLINE
DCOM- 20071217
LR  - 20190513
IS  - 1672-9145 (Print)
IS  - 1672-9145 (Linking)
VI  - 39
IP  - 9
DP  - 2007 Sep
TI  - Induction of cytotoxic T lymphocytes specific to malignant glioma using T2 cells 
      pulsed with HLA-A2-restricted interleukin-13 receptor alpha 2 peptide in vitro.
PG  - 641-8
AB  - Interleukin-13 receptor alpha2 (IL-13Ralpha2) is a glioma-restricted cell-surface 
      epitope not otherwise detected within the central nervous system. The present 
      study is a report of a novel approach of targeting malignant glioma with 
      IL-13Ralpha2-specific cytotoxic T lymphocyte (CTL) induced from the peripheral 
      blood mononuclear cells of healthy donors by multiple stimulations with human 
      leukocyte antigen (HLA)-A2-restricted IL-13Ralpha2(345-353) peptide-pulsed T2 
      cells. The induced CTL showed specific lysis against T2 cells pulsed with the 
      peptide and HLA-A2+ glioma cells expressing IL-13R2(345-353), while HLA-A2 glioma 
      cell lines that express IL-13Ralpha2(345-353) could not be recognized by CTL. The 
      peptide-specific activity was inhibited by anti-HLA class I monoclonal antibody. 
      These results suggest that the induced CTL specific for IL-13Ralpha2(345-353) 
      peptide could be a potential target of specific immunotherapy for HLA-A2 patients 
      with malignant glioma.
FAU - Jiang, Xiaobing
AU  - Jiang X
AD  - Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China. jxb917@126.com
FAU - Lu, Xiaoling
AU  - Lu X
FAU - Liu, Ru'en
AU  - Liu R
FAU - Zhang, Fangcheng
AU  - Zhang F
FAU - Zhao, Hongyang
AU  - Zhao H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Interleukin-13 Receptor alpha2 Subunit)
RN  - 0 (Peptides)
SB  - IM
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Coculture Techniques
MH  - Glioma/*immunology/pathology
MH  - HLA-A2 Antigen/*immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Interleukin-13 Receptor alpha2 Subunit/biosynthesis/genetics/*immunology
MH  - Lymphocyte Activation/*immunology
MH  - Peptides/*immunology/metabolism
MH  - T-Lymphocytes, Cytotoxic/*immunology/metabolism
EDAT- 2007/09/07 09:00
MHDA- 2007/12/18 09:00
CRDT- 2007/09/07 09:00
PHST- 2007/09/07 09:00 [pubmed]
PHST- 2007/12/18 09:00 [medline]
PHST- 2007/09/07 09:00 [entrez]
AID - 10.1111/j.1745-7270.2007.00331.x [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2007 Sep;39(9):641-8. doi: 
      10.1111/j.1745-7270.2007.00331.x.