PMID- 17822659
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20070907
IS  - 0953-6205 (Print)
IS  - 0953-6205 (Linking)
VI  - 18
IP  - 6
DP  - 2007 Oct
TI  - Relation between plasma homocysteine, gene polymorphisms of homocysteine 
      metabolism-related enzymes, and angiographically proven coronary artery disease.
PG  - 474-83
AB  - BACKGROUND: Hyperhomocyteinemia (HHcy) is a risk factor for coronary artery 
      disease (CAD), and methylenetetrahydrofolate reductase (MTHFR), methionine 
      synthase (MTR), and methionine synthase reductase (MTRR) polymorphisms may 
      contribute to plasma total homocysteine (tHcy) variation. We investigated the 
      association of polymorphisms 1298A-->C in the MTHFR gene, 2756A-->G in the MTR 
      gene, and 66A-->G in the MTRR gene with tHcy levels and with CAD in patients 
      undergoing coronary angiography. METHODS: CAD patients (n=151) and control 
      subjects (n=79) were compared regarding the prevalence of the polymorphisms, risk 
      factors, and biochemical parameters. RESULTS: The mean tHcy concentration was 
      significantly higher in CAD patients than in control subjects (P<0.001). HHcy 
      (tHcy>/=15 mumol/l) conferred an OR of CAD of 4.1 (95% CI 2.2-7.5, P<0.001). In 
      both cases and controls, smokers had a higher tHcy level than non-smokers and 
      demonstrated a markedly increased risk for CAD (OR=2.5, 95% CI 1.7-3.3, P<0.001). 
      The allele frequencies of the MTHFR 1298A-->C, MTR 2756A-->G, and MTRR 66A-->G 
      mutations were 36.7%, 15.7%, and 36.6%, respectively. The 1298C allele frequency 
      was significantly higher in the CAD group than in controls (P<0.05) and showed a 
      significant association with CAD in heterozygote carriers. There was no 
      statistically significant difference between cases and controls in the 
      frequencies of the A2756G alleles/genotypes in the MTR gene and of the A66G 
      alleles/genotypes in the MTRR gene. The contributions to tHcy levels of the three 
      common mutations were statistically significant. The heterozygosity of the MTHFR 
      1298AC genotype, MTR 2756G allele, and MTRR 66G allele yielded an OR of 3.4, 2.0, 
      and 2.1, respectively, for having HHcy. CONCLUSION: We suggest that HHcy confers 
      a risk for CAD, and smokers with tHcy are at a greatly increased risk. Our 
      finding supports an important role of the MTHFR gene in CAD and provides evidence 
      of polygenic regulation of tHcy.
FAU - Laraqui, Abdelilah
AU  - Laraqui A
AD  - Ligue Nationale de Lutte Contre les Maladies Cardiovasculaires, Unite d'Etudes 
      des Facteurs Metaboliques et Polymorphismes Genetiques, Rabat, Morocco; UFR 
      Biochimie Immunologie, Faculte des Sciences, Universite Mohamed V. Rabat, 
      Morocco; Laboratoire de Biochimie Medicale A, Unite Fonctionnelle 
      Endocrinologie-Moleculaire-Oncologie, CHU Pitie-Salpetriere, Paris, France.
FAU - Allami, Abdellatif
AU  - Allami A
FAU - Carrie, Alain
AU  - Carrie A
FAU - Raisonnier, Alain
AU  - Raisonnier A
FAU - Coiffard, Anne-Sofie
AU  - Coiffard AS
FAU - Benkouka, Fatima
AU  - Benkouka F
FAU - Bendriss, Abdenabi
AU  - Bendriss A
FAU - Benjouad, Abdelaziz
AU  - Benjouad A
FAU - Bennouar, N
AU  - Bennouar N
FAU - El Kadiri, Nizar
AU  - El Kadiri N
FAU - Benomar, Anwar
AU  - Benomar A
FAU - Fellat, Seddik
AU  - Fellat S
FAU - Benomar, Mohamed
AU  - Benomar M
LA  - eng
PT  - Journal Article
DEP - 20070712
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
EDAT- 2007/09/08 09:00
MHDA- 2007/09/08 09:01
CRDT- 2007/09/08 09:00
PHST- 2006/05/31 00:00 [received]
PHST- 2006/11/12 00:00 [revised]
PHST- 2007/02/15 00:00 [accepted]
PHST- 2007/09/08 09:00 [pubmed]
PHST- 2007/09/08 09:01 [medline]
PHST- 2007/09/08 09:00 [entrez]
AID - S0953-6205(07)00151-3 [pii]
AID - 10.1016/j.ejim.2007.02.020 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2007 Oct;18(6):474-83. doi: 10.1016/j.ejim.2007.02.020. Epub 
      2007 Jul 12.