PMID- 17822911
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20181113
IS  - 0969-9961 (Print)
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 29
IP  - 1
DP  - 2008 Jan
TI  - The hyperbaric oxygen preconditioning-induced brain protection is mediated by a 
      reduction of early apoptosis after transient global cerebral ischemia.
PG  - 1-13
AB  - We hypothesized that the brain-protective effect of hyperbaric oxygen (HBO) 
      preconditioning in a transient global cerebral ischemia rat model is mediated by 
      the inhibition of early apoptosis. One hundred ten male Sprague-Dawley (SD) rats 
      (300-350 g body weight) were allocated to the sham group and three other groups 
      with 10 min of four-vessel occlusion, untreated or preconditioned with either 3 
      or 5 hyperbaric oxygenations. HBO preconditioning improved neurobehavioral scores 
      and reduced mortality, decreased ischemic cell change, reduced the number of 
      early apoptotic cells and hampered a conversion of early to late apoptotic 
      alterations. HBO preconditioning reduced the immunoreactivity of phosphorylated 
      p38 in vulnerable neurons and increased the expression of brain derived 
      neurotrophic factor (BDNF) in early stage post-ischemia. However, preconditioning 
      with 3 HBO treatments proved less beneficial than with 5 HBO treatments. We 
      conclude that HBO preconditioning may be neuroprotective by reducing early 
      apoptosis and inhibition of the conversion of early to late apoptosis, possibly 
      through an increase in brain BDNF level and the suppression of p38 activation.
FAU - Ostrowski, Robert P
AU  - Ostrowski RP
AD  - Department of Physiology and Pharmacology, Loma Linda University School of 
      Medicine, Loma Linda, CA 92350, USA.
FAU - Graupner, Gerhart
AU  - Graupner G
FAU - Titova, Elena
AU  - Titova E
FAU - Zhang, Jennifer
AU  - Zhang J
FAU - Chiu, Jeffrey
AU  - Chiu J
FAU - Dach, Neal
AU  - Dach N
FAU - Corleone, Dalia
AU  - Corleone D
FAU - Tang, Jiping
AU  - Tang J
FAU - Zhang, John H
AU  - Zhang JH
LA  - eng
GR  - NS53407/NS/NINDS NIH HHS/United States
GR  - NS52492/NS/NINDS NIH HHS/United States
GR  - R01 NS053407/NS/NINDS NIH HHS/United States
GR  - R01 HD043120/HD/NICHD NIH HHS/United States
GR  - R01 HD043120-05/HD/NICHD NIH HHS/United States
GR  - R01 NS053407-02/NS/NINDS NIH HHS/United States
GR  - R01 NS045694/NS/NINDS NIH HHS/United States
GR  - R21 NS052492/NS/NINDS NIH HHS/United States
GR  - NS43338/NS/NINDS NIH HHS/United States
GR  - R01 NS043338/NS/NINDS NIH HHS/United States
GR  - NS45694/NS/NINDS NIH HHS/United States
GR  - R01 NS043338-05/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070728
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Annexin A5)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Annexin A5/metabolism
MH  - Apoptosis/*physiology
MH  - Astrocytes/metabolism/pathology
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Caspase 3/metabolism
MH  - Cell Count/methods
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Gait Disorders, Neurologic/etiology
MH  - *Hyperbaric Oxygenation
MH  - In Situ Nick-End Labeling/methods
MH  - Ischemic Attack, Transient/complications/mortality/*pathology/prevention & 
      control
MH  - Ischemic Preconditioning/*methods
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Severity of Illness Index
MH  - Time Factors
PMC - PMC2190110
MID - NIHMS36374
EDAT- 2007/09/08 09:00
MHDA- 2008/03/15 09:00
PMCR- 2009/01/01
CRDT- 2007/09/08 09:00
PHST- 2007/05/02 00:00 [received]
PHST- 2007/06/25 00:00 [revised]
PHST- 2007/07/17 00:00 [accepted]
PHST- 2007/09/08 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2007/09/08 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - S0969-9961(07)00171-4 [pii]
AID - 10.1016/j.nbd.2007.07.020 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2008 Jan;29(1):1-13. doi: 10.1016/j.nbd.2007.07.020. Epub 2007 Jul 
      28.