PMID- 17823444
OWN - NLM
STAT- MEDLINE
DCOM- 20080307
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 86
IP  - 3
DP  - 2007 Sep
TI  - Genetic polymorphisms of tumor necrosis factor-alpha modify the association 
      between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo 
      A-I concentrations.
PG  - 768-74
AB  - BACKGROUND: Heterogeneity in circulating lipid concentrations in response to 
      dietary polyunsaturated fatty acids (PUFAs) may be due, in part, to genetic 
      variations. Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine 
      that can induce hyperlipidemia and is known to be modulated by dietary PUFAs. 
      OBJECTIVE: The objective was to determine whether TNF-alpha genotypes modify the 
      association between dietary PUFA intake and serum lipid concentrations. DESIGN: 
      The study involved 53 men and 56 women aged 42-75 y with type 2 diabetes. Dietary 
      intakes were assessed with the use of a 3-d food record, and blood samples were 
      collected to determine fasting serum lipids. DNA was isolated from blood for 
      genotyping by polymerase chain reaction-restriction fragment length polymorphism 
      for the TNF-alpha -238G-->A and -308G-->A polymorphisms. RESULTS: PUFA intake was 
      positively associated with serum HDL cholesterol in carriers of the -238A allele 
      (beta = 0.06 +/- 0.03 mmol/L per 1% of energy from PUFAs; P = 0.03), but 
      negatively associated in those with the -238GG genotype (beta = -0.03 +/- 0.01, P 
      = 0.03) (P = 0.004 for interaction). PUFA intake was inversely associated with 
      HDL cholesterol in carriers of the -308A allele (beta = -0.07 +/- 0.02, P = 
      0.002), but not in those with the -308GG genotype (beta = 0.02 +/- 0.02, P = 
      0.13) (P = 0.001 for interaction). A stronger gene x diet interaction was 
      observed when the polymorphisms at the 2 positions (-238/-308) were combined (P = 
      0.0003). Similar effects were observed for apolipoprotein A-I, but not with other 
      dietary fatty acids and serum lipids. CONCLUSION: TNF-alpha genotypes modify the 
      relation between dietary PUFA intake and HDL-cholesterol concentrations. These 
      findings suggest that genetic variations affecting inflammation may explain some 
      of the inconsistencies between previous studies relating PUFA intake and 
      circulating HDL.
FAU - Fontaine-Bisson, Benedicte
AU  - Fontaine-Bisson B
AD  - Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, 
      Canada.
FAU - Wolever, Thomas M S
AU  - Wolever TM
FAU - Chiasson, Jean-Louis
AU  - Chiasson JL
FAU - Rabasa-Lhoret, Remi
AU  - Rabasa-Lhoret R
FAU - Maheux, Pierre
AU  - Maheux P
FAU - Josse, Robert G
AU  - Josse RG
FAU - Leiter, Lawrence A
AU  - Leiter LA
FAU - Rodger, N Wilson
AU  - Rodger NW
FAU - Ryan, Edmond A
AU  - Ryan EA
FAU - Connelly, Philip W
AU  - Connelly PW
FAU - Corey, Paul N
AU  - Corey PN
FAU - El-Sohemy, Ahmed
AU  - El-Sohemy A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Apolipoprotein A-I/*blood
MH  - Cholesterol, HDL/*blood
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diet Records
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Fasting/blood
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrigenomics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2007/09/08 09:00
MHDA- 2008/03/08 09:00
CRDT- 2007/09/08 09:00
PHST- 2007/09/08 09:00 [pubmed]
PHST- 2008/03/08 09:00 [medline]
PHST- 2007/09/08 09:00 [entrez]
AID - S0002-9165(23)30290-9 [pii]
AID - 10.1093/ajcn/86.3.768 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2007 Sep;86(3):768-74. doi: 10.1093/ajcn/86.3.768.