PMID- 17823690
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20200622
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Print)
IS  - 1613-6071 (Linking)
VI  - 4
IP  - 2
DP  - 2007 Summer
TI  - The cross-regulatory relationship between human dendritic and regulatory T cells 
      and its role in type 1 diabetes mellitus.
PG  - 68-76
AB  - Dendritic cells (DCs) and T regulatory (Treg) cells play a crucial role in 
      maintaining the tolerance needed to prevent the onset of autoimmunity that leads 
      to the development of type 1 diabetes mellitus (T1DM). Various experimental 
      studies have shown that human DC subsets are involved in the induction of anergy 
      in T cells and in the differentiation of conventional CD4(+) and CD8(+) 
      lymphocytes into the respective subtypes of Treg cells. Treg cells, in turn, have 
      been shown to modulate the function of DCs to exhibit tolerogenic properties. To 
      evaluate whether T1DM development is related to abnormalities in DCs and Treg 
      cells, many attempts have been made to characterize these cell types in diabetic 
      individuals and in subjects at risk of developing the disease. This review aims 
      to supply an update on the progress made in these aspects of T1DM research.
FAU - Chang, Hsuen-Wen
AU  - Chang HW
AD  - Vaccine Center, National Health Research Institutes, Zhunan Township, Miaoli 
      County, Taiwan 350.
FAU - Chow, Yen-Hung
AU  - Chow YH
FAU - Chong, Pele
AU  - Chong P
FAU - Sia, Charles
AU  - Sia C
LA  - eng
PT  - Journal Article
DEP - 20070810
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
PMC - PMC2036261
EDAT- 2007/09/08 09:00
MHDA- 2007/09/08 09:01
PMCR- 2008/08/10
CRDT- 2007/09/08 09:00
PHST- 2007/09/08 09:00 [pubmed]
PHST- 2007/09/08 09:01 [medline]
PHST- 2007/09/08 09:00 [entrez]
PHST- 2008/08/10 00:00 [pmc-release]
AID - 10.1900/RDS.2007.4.68 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2007 Summer;4(2):68-76. doi: 10.1900/RDS.2007.4.68. Epub 2007 
      Aug 10.