PMID- 17825148
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20070910
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 87
IP  - 24
DP  - 2007 Jun 26
TI  - [Cytogenetic characteristics of patients with multiple myeloma in China: analysis 
      of 100 case].
PG  - 1685-8
AB  - OBJECTIVE: To summarize the cytogenetic characteristics of patients with multiple 
      myeloma (MM) in China and clinical significance thereof. METHODS: Specimens of 
      bone marrow were collected from 100 patients with MM who visited the Institute of 
      Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences in 
      Tianjin, China. Chromosome banding analysis and fluorescence in situ 
      hybridization (FISH) were conducted. RESULTS: (1) Clonal chromosome aberrations 
      (CA) were detected in 16 of 93 patients (17.2%) by conventional cytogenetics 
      (CC), and when subclonal CA was included CA were detected in 37.0% of the 
      patients. Numerical aberration analysis showed that the most common trisomies 
      were 11, 21, 3, 6, and 12, and the most common monosomies were 16, 13, 8, 22, and 
      11. Structural aberration analysis showed that the most frequently involved arms 
      were 14q, 8q, 1q, 6q, 11q, 12p, and 1p, and the most frequently involved 
      breakpoints were 14q32, 8q22 - 24, 11q13 - 14, 6p21, 1q10 - 11, and 12p12 - 13. 
      Ploidy level was arranged in decreasing order as: hypodiploidy (46.1%), 
      pseudodiploid (38.5%), hyperdiploidy (18.8%), and tri-/tetraploidy (15.4%). 
      Chromosome 13 abnormality (C13A) was detected in 7 of the 100 patients (7%). The 
      C13A prevalence rates by CC and interphase FISH were 6.0% and 33.3% respectively. 
      Translocations involving chromosome 14 and/or 14q32 aberrations were detected in 
      6 patients (6.0%). (2) Univariate analysis showed that C13A, nonhyperdiploidy, 
      and clonal CA were associated with significantly shorter overall survival (OS) 
      and time to progression (TTP). Multivariate analysis showed that C13A was the 
      only independent unfavorable factor. CONCLUSION: The concrete CA of the patients 
      with MM in China are comparable to those from Western countries, among which 
      C13A, nonhyperdiploidy, hyperdiploidy, and translocations involving 
      immunoglobulin heavy chain locus (IgH) are recurrent. C13A, nonhyperdiploidy, and 
      clonal CA are associated with shorter OS and time-to-progression, and C13A is the 
      only independent adverse prognostic factor.
FAU - Deng, Shu-hui
AU  - Deng SH
AD  - Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Tianjin 300020, China.
FAU - Xu, Yan
AU  - Xu Y
FAU - Wang, Ya-fei
AU  - Wang YF
FAU - Mai, Yu-jie
AU  - Mai YJ
FAU - Liu, Xu-ping
AU  - Liu XP
FAU - Zhao, Yao-zhong
AU  - Zhao YZ
FAU - Zou, De-hui
AU  - Zou DH
FAU - Wang, Ying
AU  - Wang Y
FAU - Qiu, Lu-gui
AU  - Qiu LG
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - *Chromosome Aberrations
MH  - Cytogenetic Analysis/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology
MH  - Retrospective Studies
EDAT- 2007/09/11 09:00
MHDA- 2008/11/01 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2007 Jun 26;87(24):1685-8.