PMID- 17825154
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20070910
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 87
IP  - 24
DP  - 2007 Jun 26
TI  - [The study on the chromosome aneuploidy in human lung cancer].
PG  - 1701-3
AB  - OBJECTIVE: To study the feasibility of interphase fluorescence in situ 
      hybridization (FISH) in detection of chromosomal aneuploidy in touch preparations 
      of lung carcinoma and its clinic significance. METHODS: We examined 46 touch 
      preparations of lung carcinomas by FISH with DNA specific for chromosomes 7, 8, 9 
      and 12 to detect chromosomal aneuploidy. RESULTS: Aneuploidy, mainly featured in 
      gains of chromosomes 7, 8 and 12 and loss of chromosome 9 were observed in all of 
      the touch preparations of the 46 cases with lung cancer. The rates of chromosomal 
      aneuploidy detected by FISH were 67.4% (31/46), 60.9% (28/46), 28.3% (13/46) and 
      56.5% (26/31) respectively. CONCLUSION: Interphase FISH is feasible in detecting 
      aneuploidy in touch preparations of lung cancer. These alterations may be applied 
      to early diagnosis and predicting prognosis of lung cancer.
FAU - Gao, Shu-geng
AU  - Gao SG
AD  - Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Science and Peking Union Medical College, Beijing 100021, China.
FAU - Dong, Xiang-yang
AU  - Dong XY
FAU - Wang, Liang-jun
AU  - Wang LJ
FAU - He, Jie
AU  - He J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - *Aneuploidy
MH  - Carcinoma, Small Cell/genetics/pathology
MH  - Carcinoma, Squamous Cell/genetics/pathology
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Neoplasm Staging
MH  - Reproducibility of Results
EDAT- 2007/09/11 09:00
MHDA- 2008/11/01 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2007 Jun 26;87(24):1701-3.