PMID- 17825920
OWN - NLM
STAT- MEDLINE
DCOM- 20080527
LR  - 20090928
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 107
IP  - 1-3
DP  - 2008 Apr
TI  - Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers: 
      no effects on brain-derived neurotrophic factor (BDNF) concentrations in serum.
PG  - 255-8
AB  - BACKGROUND: Transcranial magnetic stimulation (TMS) of the dorsolateral 
      prefrontal cortex is a brain stimulation technique widely used to treat 
      depression. BDNF serum concentrations have been shown to be decreased in patients 
      with major depressive disorder and can be upregulated by several antidepressive 
      treatment strategies including repetitive TMS. METHODS: In this study we were 
      interested whether acute TMS evolves effects on serum BDNF concentrations in 42 
      healthy volunteers. RESULTS: Mean BDNF serum concentration in 19 male and 23 
      female volunteers was 10.70+/-3.6 ng/ml (n=42) at baseline, and 10.76+/-3.9 ng/ml 
      (n=42) after TMS treatment. BDNF serum levels did not change after acute TMS 
      (n=42, Z=-0.44, p=0.965). BDNF serum concentrations at baseline did not differ 
      between male (n=19, 10.05+/-2.6 ng/ml) and female (n=23, 11.25+/-4.27 ng/ml) 
      participants of the study (n=42, Z=-0.91, p=0.363). CONCLUSIONS: Our result 
      suggests that TMS does not change BDNF serum concentrations immediately in 
      healthy human volunteers.
FAU - Lang, Undine E
AU  - Lang UE
AD  - Department of Psychiatry and Psychotherapy, Charite-University Medicine Berlin, 
      Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany. undine.lang@charite.de
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Gallinat, Juergen
AU  - Gallinat J
FAU - Bajbouj, Malek
AU  - Bajbouj M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070907
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder/blood/therapy
MH  - Female
MH  - Functional Laterality/physiology
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - Sex Factors
MH  - Transcranial Magnetic Stimulation/*methods
EDAT- 2007/09/11 09:00
MHDA- 2008/05/28 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/03/26 00:00 [received]
PHST- 2007/08/13 00:00 [revised]
PHST- 2007/08/13 00:00 [accepted]
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2008/05/28 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - S0165-0327(07)00290-X [pii]
AID - 10.1016/j.jad.2007.08.008 [doi]
PST - ppublish
SO  - J Affect Disord. 2008 Apr;107(1-3):255-8. doi: 10.1016/j.jad.2007.08.008. Epub 
      2007 Sep 7.