PMID- 17826409
OWN - NLM
STAT- MEDLINE
DCOM- 20070919
LR  - 20111117
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 197
IP  - 3
DP  - 2007 Sep
TI  - Reduced third-trimester levels of soluble human leukocyte antigen G protein in 
      severe preeclampsia.
PG  - 255.e1-5
AB  - OBJECTIVE: Recently, lower maternal plasma human leukocyte antigen (HLA)-G 
      protein levels in preeclampsia (PE) in the first and second trimester was 
      reported. Thus, we sought to evaluate the levels of HLA-G protein in patients 
      with severe PE during the third trimester. STUDY DESIGN: In this prospective case 
      control study, amniotic fluid and maternal and cord blood samples were aspirated 
      from 50 pregnant women during the third trimester. The study group included 26 
      pregnant women diagnosed with severe PE and 24 women without PE serving as 
      controls. A soluble HLA-G-specific enzyme-linked immunosorbent assay was used to 
      measure protein levels. Statistical analysis included the Student t test and 
      simple regression analysis. RESULTS: Maternal serum HLA-G levels in PE 
      pregnancies were found to be significantly lower as compared with normal 
      pregnancies (10.97 +/- 6.55 vs 36.05 +/- 34.53 microg/mL; P = .003). CONCLUSION: 
      A reduced level of maternal HLA-G protein was associated with severe PE during 
      the third trimester. This finding may suggest an essential role for HLA-G in 
      normal and preeclamptic pregnancies.
FAU - Hackmon, Rinat
AU  - Hackmon R
AD  - Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. 
      rhackmon@gmail.com
FAU - Koifman, Arie
AU  - Koifman A
FAU - Hyodo, Hironobu
AU  - Hyodo H
FAU - Glickman, Hagit
AU  - Glickman H
FAU - Sheiner, Eyal
AU  - Sheiner E
FAU - Geraghty, Daniel E
AU  - Geraghty DE
LA  - eng
GR  - R01 HD045813/HD/NICHD NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
EIN - Am J Obstet Gynecol. 2008 Feb;198(2):245. Hyobo, Hirohito [corrected to Hyodo, 
      Hironobu]
MH  - Amniotic Fluid/chemistry
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Blood/chemistry
MH  - HLA Antigens/*blood
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*blood
MH  - Humans
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Pregnancy Trimester, Third/blood
MH  - Prospective Studies
EDAT- 2007/09/11 09:00
MHDA- 2007/09/20 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/03/12 00:00 [received]
PHST- 2007/05/21 00:00 [revised]
PHST- 2007/06/15 00:00 [accepted]
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2007/09/20 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - S0002-9378(07)00762-4 [pii]
AID - 10.1016/j.ajog.2007.06.033 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2007 Sep;197(3):255.e1-5. doi: 10.1016/j.ajog.2007.06.033.