PMID- 17826952
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20081121
IS  - 0896-8411 (Print)
IS  - 0896-8411 (Linking)
VI  - 29
IP  - 4
DP  - 2007 Dec
TI  - Homeostatic roles of naturally occurring antibodies: an overview.
PG  - 287-94
AB  - Immunoglobulins may have been developed in evolution to provide specificity for 
      clearing body waste in the first animals with three germ layers. Tissue 
      homeostasis in vertebrates comprises clearance of proteins released from lysed 
      cells, elimination of altered plasma proteins, of senescent and apoptotic cells. 
      Rather specific IgM and IgG naturally occurring antibodies (NAbs) to cytoplasmic 
      and cytoskeletal proteins bind to proteins released from lysing cells and the IgG 
      NAbs are slightly upregulated upon demand. Some of these NAbs along with 
      complement have devastating effects when massive amounts of intracellular 
      proteins are released during an infarct or an ischemia/reperfusion experiment. 
      IgM NAbs to neoepitopes on plasma proteins/lipids help clear denatured proteins 
      and are protective. IgG NAbs to an exposed protein, band 3 from red blood cells, 
      bind to oligomerized band 3 and due to an affinity for C3 within their framework 
      preferentially form C3b2-IgG complexes from nascent C3b. Thus, anti-band 3 NAbs 
      gain potency by using avidity and generating a potent precursor of the amplifying 
      C3 convertase. IgM NAbs to neoepitopes, which are generated by oxidized lipids 
      forming Schiff bases with proteins, are protective and help clear this waste in 
      atherosclerosis, but IgG antibodies (NAbs?) of the same specificity promote 
      disease.
FAU - Lutz, Hans U
AU  - Lutz HU
AD  - Institute of Biochemistry, ETH Zurich, Schafmattstr. 18, CH 8093 Zurich, 
      Switzerland. hlutz@bc.biol.ethz.ch
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070912
PL  - England
TA  - J Autoimmun
JT  - Journal of autoimmunity
JID - 8812164
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - *Autoantibodies
MH  - *Autoantigens
MH  - Homeostasis/*immunology
MH  - Humans
MH  - *Immunity, Innate
RF  - 61
EDAT- 2007/09/11 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - S0896-8411(07)00089-3 [pii]
AID - 10.1016/j.jaut.2007.07.007 [doi]
PST - ppublish
SO  - J Autoimmun. 2007 Dec;29(4):287-94. doi: 10.1016/j.jaut.2007.07.007. Epub 2007 
      Sep 12.