PMID- 17827391
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 110
IP  - 13
DP  - 2007 Dec 15
TI  - Development of plasmacytoid dendritic cells in bone marrow stromal cell niches 
      requires CXCL12-CXCR4 chemokine signaling.
PG  - 4153-60
AB  - Plasmacytoid dendritic cells (pDCs), also known as type I interferon 
      (IFN)-producingcells, are thought to play central roles in antiviral immunity and 
      the pathogenesis of some autoimmune diseases. pDCs are produced from 
      hematopoietic stem cells in bone marrow. However, the environmental regulation of 
      the development of pDCs is not fully understood. Here, we show that the numbers 
      of pDCs and their earliest progenitors are severely reduced in the absence of 
      CXCR4, the primary physiologic receptor for CXC chemokine ligand 12 (CXCL12), 
      also known as stromal cell-derived factor-1 (SDF-1) in vivo. In vitro, CXCL12 
      induces a significant increase in pDC numbers generated from primitive 
      hematopoietic cells, and pDCs and their progenitors migrate to CXCL12. In 
      addition, most pDCs are in contact with CXCL12-abundant reticular (CAR) cells in 
      the intersinal space of bone marrow, although many primitive hematopoietic cells 
      adjoin CAR cells surrounding sinusoidal endothelial cells or residing near the 
      bone surface. Thus we identified CXCL12 as a key regulator of pDC development 
      produced by cellular niches, providing new targets for pDC therapeutic control.
FAU - Kohara, Hiroshi
AU  - Kohara H
AD  - Department of Immunobiology and Hematology, Institute for Frontier Medical 
      Sciences, Kyoto University, Kyoto, Japan.
FAU - Omatsu, Yoshiki
AU  - Omatsu Y
FAU - Sugiyama, Tatsuki
AU  - Sugiyama T
FAU - Noda, Mamiko
AU  - Noda M
FAU - Fujii, Nobutaka
AU  - Fujii N
FAU - Nagasawa, Takashi
AU  - Nagasawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070907
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cxcl12 protein, mouse)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - *Bone Marrow
MH  - Cell Count
MH  - Cell Movement
MH  - Chemokine CXCL12/*physiology
MH  - Dendritic Cells/*cytology
MH  - Genotype
MH  - Hematopoietic Stem Cells
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Receptors, CXCR4/*physiology
MH  - *Signal Transduction
MH  - Stromal Cells/*cytology
EDAT- 2007/09/11 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - S0006-4971(20)52854-1 [pii]
AID - 10.1182/blood-2007-04-084210 [doi]
PST - ppublish
SO  - Blood. 2007 Dec 15;110(13):4153-60. doi: 10.1182/blood-2007-04-084210. Epub 2007 
      Sep 7.