PMID- 17827748
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20221207
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 30
IP  - 9
DP  - 2007 Sep
TI  - Effects of oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on 
      monoamine neurotransmission in the rat brain.
PG  - 1816-8
AB  - As abnormal behaviors such as jumping and falling from balcony were reported in 
      patients aged 10 to 19 years who administrated oseltamivir phosphate (Tamiflu) 
      for treatment influenza infection, the Ministry of Health, Labor and Welfare in 
      Japan notified that, as a rule, Tamiflu should not be prescribed to patients aged 
      10 to 19 years. To examine the relationship between Tamiflu and abnormal 
      behaviors, we investigated the effects of Tamiflu and its carboxylic acid 
      metabolite, GS4071, on the central nervous system, that is, on 3 
      neurotransmitters (dopamine, serotonin, and norepinephrine) in presynapses 
      (inhibition of re-uptake, promotion of release) and postsynapses (guanosine 
      5'-triphosphate (GTP) gammaS binding), using rat brain synaptosomes. Neither 
      Tamiflu nor GS4071 influenced the re-uptake/release of the 3 monoamines or GTP 
      binding in postsynapses.
FAU - Satoh, Kanako
AU  - Satoh K
AD  - Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute 
      of Public Health, Shinjuku-ku, Tokyo 169-0073, Japan. 
      Kanako_Satou@member.metro.tokyo.jp
FAU - Nonaka, Ryouichi
AU  - Nonaka R
FAU - Ogata, Akio
AU  - Ogata A
FAU - Nakae, Dai
AU  - Nakae D
FAU - Uehara, Shin-Ichi
AU  - Uehara S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Antiviral Agents)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 20O93L6F9H (Oseltamivir)
RN  - 333DO1RDJY (Serotonin)
RN  - 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate))
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Biogenic Monoamines/*physiology
MH  - Brain Chemistry/*drug effects
MH  - Dopamine/metabolism
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Guanosine 5'-O-(3-Thiotriphosphate)/metabolism
MH  - Guanosine Triphosphate/metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Norepinephrine/metabolism
MH  - Oseltamivir/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Synaptic Transmission/*drug effects
MH  - Synaptosomes/drug effects/metabolism
EDAT- 2007/09/11 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - JST.JSTAGE/bpb/30.1816 [pii]
AID - 10.1248/bpb.30.1816 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2007 Sep;30(9):1816-8. doi: 10.1248/bpb.30.1816.