PMID- 17827934
OWN - NLM
STAT- MEDLINE
DCOM- 20071024
LR  - 20131121
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 25
IP  - 3
DP  - 2007
TI  - Functional heartburn and non-erosive reflux disease.
PG  - 172-4
AB  - Gastroesophageal reflux disease (GERD) is a common disorder in Western countries. 
      For many years our attention has been focused on patients with erosive 
      esophagitis, but in recent times we have realized that endoscopy-negative reflux 
      disease is the most common presentation of this illness, affecting up to 70% of 
      these individuals. Patients with the non-erosive form (NERD) are a heterogeneous 
      group including various subpopulations with different mechanisms for their main 
      symptom of heartburn: reflux of acidic and non-acidic gastric contents, mucosal 
      hypersensitivity, intraesophageal distension by gas, intraduodenal infusion of 
      fat, muscle contractions and psychological abnormalities. As to esophageal acid 
      exposure, patients with NERD can be subdivided into those with abnormal and 
      normal pH testing. The latter group includes patients with a positive correlation 
      between symptoms and reflux events, in whom heartburn can be controlled by proton 
      pump inhibitor (PPI) therapy. According to the recent Rome III criteria, they are 
      still in the realm of GERD. An additional group is called functional heartburn, 
      because this typical symptom is associated neither with an abnormal pH test nor 
      with a positive symptom index. Their response to PPIs is very disappointing. 
      Therefore, there is an increasing consensus on the fact that they do not have 
      GERD and should be treated with drugs other than PPIs.
CI  - 2007 S. Karger AG, Basel
FAU - Savarino, Vincenzo
AU  - Savarino V
AD  - Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di 
      Genova, Genova, Italy. vsavarin@unige.it
FAU - Savarino, Edoardo
AU  - Savarino E
FAU - Parodi, Andrea
AU  - Parodi A
FAU - Dulbecco, Pietro
AU  - Dulbecco P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Enzyme Inhibitors/pharmacology/therapeutic use
MH  - Gastroesophageal Reflux/*physiopathology
MH  - Heartburn/drug therapy/*physiopathology
MH  - Humans
MH  - Proton Pump Inhibitors
MH  - Treatment Failure
RF  - 15
EDAT- 2007/09/11 09:00
MHDA- 2007/10/25 09:00
CRDT- 2007/09/11 09:00
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2007/10/25 09:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - 000103879 [pii]
AID - 10.1159/000103879 [doi]
PST - ppublish
SO  - Dig Dis. 2007;25(3):172-4. doi: 10.1159/000103879.