PMID- 17828499
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20181113
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 27
IP  - 4
DP  - 2007 Aug
TI  - Effect of transcranial magnetic stimulation on the expression of c-Fos and 
      brain-derived neurotrophic factor of the cerebral cortex in rats with cerebral 
      infarct.
PG  - 415-8
AB  - The effect of transcranial magnetic stimulation (TMS) on the neurological 
      functional recovery and expression of c-Fos and brain-derived neurotrophic factor 
      (BDNF) of the cerebral cortex in rats with cerebral infarction was investigated. 
      Cerebral infarction models were established by using left middle cerebral artery 
      occlusion (MCAO) and were randomly divided into a model group (n=40) and a TMS 
      group (n=40). TMS treatment (2 times per day, 30 pulses per time) with a 
      frequency of 0.5 Hz and magnetic field intensity of 1.33 Tesla was carried out in 
      TMS group after MCAO. Modified neurological severity score (NSS) were recorded 
      before and 1, 7, 14, 21, and 28 day(s) after MCAO. The expression of c-Fos and 
      BDNF was immunohistochemically detected 1, 7, 14, 21, and 28 day(s) after 
      infarction respectively. Our results showed that a significant recovery of NSS 
      (P<0.05) was found in animals treated by TMS on day 7, 14, 21, and 28 as compared 
      with the animals in the model group. The positive expression of c-Fos and BDNF 
      was detected in the cortex surrounding the infarction areas, while the expression 
      of c-Fos and BDNF increased significantly in TMS treatment group in comparison 
      with those in model group 7, 14, 21, and 28 days (P<0.05) and 7, 14, 21 days 
      (P<0.01) after infarction, respectively. It is concluded that TMS has therapeutic 
      effect on cerebral infarction and this may have something to do with TMS's 
      ability to promote the expression of c-Fos and BDNF of the cerebral cortex in 
      rats with cerebral infarction.
FAU - Zhang, Xiaoqiao
AU  - Zhang X
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China. little_bridge@126.com
FAU - Mei, Yuanwu
AU  - Mei Y
FAU - Liu, Chuanyu
AU  - Liu C
FAU - Yu, Shanchun
AU  - Yu S
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cerebral Cortex/metabolism
MH  - Cerebral Infarction/*metabolism/*therapy
MH  - Infarction, Middle Cerebral Artery/metabolism
MH  - Male
MH  - Proto-Oncogene Proteins c-fos/genetics/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Transcranial Magnetic Stimulation
EDAT- 2007/09/11 09:00
MHDA- 2010/10/27 06:00
CRDT- 2007/09/11 09:00
PHST- 2006/05/15 00:00 [received]
PHST- 2007/09/11 09:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
PHST- 2007/09/11 09:00 [entrez]
AID - 10.1007/s11596-007-0416-3 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):415-8. doi: 
      10.1007/s11596-007-0416-3.