PMID- 1782993
OWN - NLM
STAT- MEDLINE
DCOM- 19920313
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 200
IP  - 2-3
DP  - 1991 Aug 6
TI  - Modulation of the mesolimbic dopaminergic system by beta-endorphin-(1-27) as 
      assessed by microdialysis.
PG  - 319-24
AB  - In the present study we used in vivo microdialysis to examine the influence of 
      beta-endorphin-(1-27) (beta-EP-(1-27) upon beta-endorphin (beta-EP)-induced 
      dopamine (DA) release in the nucleus accumbens of anesthetized rats. 
      Microdialysis probes were inserted into the nucleus accumbens and perfusates were 
      analyzed for DA and its metabolites, dihydroxyphenylacetic acid (DOPAC) and 
      homovanillic acid (HVA), using a reversed-phase HPLC system with electrochemical 
      detection. Intracerebroventricular (i.c.v.) administration of beta-EP-(1-27) 
      (5-20 micrograms) resulted in a dose-dependent increase in DA release which was 
      smaller than the beta-EP-induced DA release, whereas metabolite levels were not 
      altered. Pretreatment with beta-EP-(1-27) (5-20 micrograms) significantly altered 
      the beta-EP (5 micrograms)-induced increase in DA release. These results indicate 
      that beta-EP-(1-27) antagonizes the beta-EP-induced release of DA in the nucleus 
      accumbens. In addition to its antagonistic properties at the beta-endorphin 
      binding site, beta-EP-(1-27) appears to be a partial agonist, inducing increased 
      DA release. These findings suggest a regulatory function for this naturally 
      occurring beta-EP fragment within the mesolimbic system.
FAU - Spanagel, R
AU  - Spanagel R
AD  - Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, 
      Martinsried, F.R.G.
FAU - Herz, A
AU  - Herz A
FAU - Shippenberg, T S
AU  - Shippenberg TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Peptide Fragments)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 66954-40-3 (beta-endorphin (1-27))
SB  - IM
MH  - Animals
MH  - Dialysis/methods
MH  - Injections, Intraventricular
MH  - Limbic System/*drug effects/metabolism
MH  - Male
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Peptide Fragments/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - beta-Endorphin/*pharmacology
EDAT- 1991/08/06 00:00
MHDA- 1991/08/06 00:01
CRDT- 1991/08/06 00:00
PHST- 1991/08/06 00:00 [pubmed]
PHST- 1991/08/06 00:01 [medline]
PHST- 1991/08/06 00:00 [entrez]
AID - 0014-2999(91)90589-I [pii]
AID - 10.1016/0014-2999(91)90589-i [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1991 Aug 6;200(2-3):319-24. doi: 10.1016/0014-2999(91)90589-i.