PMID- 17845209
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20111117
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 58
IP  - 4
DP  - 2007 Oct
TI  - Human leukocyte antigen may predict outcome of primary recurrent spontaneous 
      abortion treated with paternal lymphocyte alloimmunization therapy.
PG  - 383-7
AB  - PROBLEM: Recurrent spontaneous abortion (RSA) is defined by at least three 
      consecutive abortions in otherwise healthy couples. Paternal lymphocyte 
      alloimmunization therapy (PLAT) is an effective therapy for RSA in some cases, 
      but there are no predictive markers about the effectiveness of PLAT. METHOD OF 
      STUDY: Forty-two consecutive cases with primary RSA treated by PLAT and 23 
      controls were the subjects. Polymorphisms of human leukocyte antigen (HLA)-E, 
      HLA-G, HLA-A, HLA-B, HLA-C and HLA-DRB1 were investigated by sequenced based 
      typing. Promoter polymorphism and a 14 bp ins/del polymorphism in exon 8 were 
      also investigated for HLA-G. RESULTS: Thirty-eight RSA wives became pregnant 
      within 1 year after PLAT. Among them, 27 obtained babies (succeeded PLAT cases), 
      while 11 again aborted with no detectable chromosomal abnormalities in the 
      aborted fetuses (aborted PLAT cases). The frequencies of HLA-G*010401, A*2402, 
      B*5201, and DRB1*1502 were significantly increased in the aborted cases than 
      those in the succeeded cases or controls. Of note, HLA-G*010401 was found in all 
      aborted cases whereas it was found in 51.9% of succeeded cases (odds ratio = 
      21.4, P = 0.006, P(c) = 0.03), and the presence of HLA-G*010401 could predict the 
      abortion after PLAT with sensitivity and specificity of 100% and 48.1%, 
      respectively. CONCLUSION: Human leukocyte antigen testing may be useful for 
      predicting effectiveness of PLAT in RSA.
FAU - Kano, Takashi
AU  - Kano T
AD  - Kano Medical Cooperation Clinic, Osaka, Japan.
FAU - Mori, Takahide
AU  - Mori T
FAU - Furudono, Masako
AU  - Furudono M
FAU - Ishikawa, Hironobu
AU  - Ishikawa H
FAU - Watanabe, Hirohiko
AU  - Watanabe H
FAU - Kikkawa, Eri
AU  - Kikkawa E
FAU - Warita, Takayuki
AU  - Warita T
FAU - Onizuka, Makoto
AU  - Onizuka M
FAU - Takahashi, Megumi
AU  - Takahashi M
FAU - Maeda, Yutaka
AU  - Maeda Y
FAU - Naruse, Taeko
AU  - Naruse T
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Kimura, Akinori
AU  - Kimura A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/genetics/immunology/*therapy
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - HLA-G Antigens
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Live Birth
MH  - *Lymphocyte Transfusion
MH  - Patient Selection
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Treatment Outcome
EDAT- 2007/09/12 09:00
MHDA- 2007/10/27 09:00
CRDT- 2007/09/12 09:00
PHST- 2007/09/12 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2007/09/12 09:00 [entrez]
AID - AJI517 [pii]
AID - 10.1111/j.1600-0897.2007.00517.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2007 Oct;58(4):383-7. doi: 10.1111/j.1600-0897.2007.00517.x.