PMID- 17845300
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20221207
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 34
IP  - 5
DP  - 2007 Oct
TI  - Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian 
      population.
PG  - 317-20
AB  - Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. 
      We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of 
      IL-18 gene by allele-specific polymerase chain reaction in normal healthy 
      subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, 
      genotype and haplotype frequencies did not differ significantly between normal 
      healthy subjects and patients. The results suggest that the IL-18 gene promoter 
      polymorphisms are not associated with susceptibility or resistance to pulmonary 
      tuberculosis in south Indian population of Dravidian descent.
FAU - Harishankar, M
AU  - Harishankar M
AD  - Tuberculosis Research Center, Indian Council of Medical Research, Chetput, 
      Chennai, India.
FAU - Selvaraj, P
AU  - Selvaraj P
FAU - Rajeswari, D N
AU  - Rajeswari DN
FAU - Anand, S P
AU  - Anand SP
FAU - Narayanan, P R
AU  - Narayanan PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/*ethnology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - India/ethnology
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Tuberculosis, Pulmonary/*genetics
EDAT- 2007/09/12 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/09/12 09:00
PHST- 2007/09/12 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/09/12 09:00 [entrez]
AID - EJI714 [pii]
AID - 10.1111/j.1744-313X.2007.00714.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2007 Oct;34(5):317-20. doi: 10.1111/j.1744-313X.2007.00714.x.