PMID- 17849322
OWN - NLM
STAT- MEDLINE
DCOM- 20071129
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 13
IP  - 4
DP  - 2007 Aug
TI  - Envelope protein Us9 is required for the anterograde transport of bovine 
      herpesvirus type 1 from trigeminal ganglia to nose and eye upon reactivation.
PG  - 384-8
AB  - In this study, the authors examined the role of bovine herpesvirus type 1 (BHV-1) 
      Us9 in the anterograde transport of the virus from trigeminal ganglia (TG) to 
      nose and eye upon reactivation from latency. During primary infection, both BHV-1 
      Us9-deleted and BHV-1 Us9-rescued viruses replicated efficiently in the nasal and 
      ocular epithelium. However, upon reactivation from latency, only the BHV-1 
      Us9-rescued virus could be isolated in the nasal and ocular shedding. By 
      real-time polymerase chain reaction, comparable DNA copy numbers were detected in 
      the TGs during latency and reactivation for both the viruses. Therefore, Us9 is 
      essential for reactivation of the virus in the TG and anterograde axonal 
      transport from TG to nose and eye.
FAU - Butchi, N B
AU  - Butchi NB
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
FAU - Jones, C
AU  - Jones C
FAU - Perez, S
AU  - Perez S
FAU - Doster, A
AU  - Doster A
FAU - Chowdhury, S I
AU  - Chowdhury SI
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
RN  - 0 (US9 protein, bovine herpesvirus 1)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - DNA, Viral/analysis
MH  - Eye/virology
MH  - Herpesvirus 1, Bovine/genetics/*growth & development/*pathogenicity
MH  - Infectious Bovine Rhinotracheitis/*virology
MH  - Nose/virology
MH  - Trigeminal Ganglion/*virology
MH  - Viral Envelope Proteins/*physiology
MH  - Virulence
MH  - Virus Latency
EDAT- 2007/09/13 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/13 09:00
PHST- 2007/09/13 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/13 09:00 [entrez]
AID - 781933486 [pii]
AID - 10.1080/13550280701375433 [doi]
PST - ppublish
SO  - J Neurovirol. 2007 Aug;13(4):384-8. doi: 10.1080/13550280701375433.