PMID- 17850220
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20220321
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 31
IP  - 11
DP  - 2007 Nov
TI  - Decreased plasma brain-derived neurotrophic factor levels in patients with 
      alcohol dependence.
PG  - 1833-8
AB  - BACKGROUND: Many reports have suggested possible relationships between 
      brain-derived neurotrophic factor (BDNF) and alcohol dependence. A protective 
      effect of BDNF against ethanol-induced cell damage has been suggested, and this 
      effect may contribute to the development or maintenance of alcohol dependence. 
      This study was carried out in order to verify the significance of BDNF in alcohol 
      dependence. METHODS: Peripheral BDNF levels were measured in alcohol-dependent 
      patients and control subjects using an enzyme-linked immunosorbent assay. A 
      physician's interview and standardized questionnaire were used to obtain 
      information regarding each patient's history of alcohol consumption. RESULTS: The 
      mean BDNF level was lower in the alcohol dependence group (389.5 +/- 501.7 pg/ml) 
      than in the normal controls (822.5 +/- 420.7 pg/ml) by analysis of covariance 
      (ANCOVA) (F = 25.79, p < 0.01). The mean BDNF level was lower in the 
      alcohol-dependent patients with a positive family history of alcohol dependence 
      (247.6 +/- 289.2 pg/ml) than in those with a negative family history of alcohol 
      dependence (583.9 +/- 652.8 pg/ml) by ANCOVA (F = 6.51, p = 0.01). The BDNF 
      levels did not correlate significantly with any of the variables analyzed in this 
      study, including Beck depression inventory, state and trait anxiety inventory 
      (STAI-S and T), and various drinking behaviors. CONCLUSIONS: Changes in the 
      levels of BDNF might play a role in the pathophysiology and inheritance of 
      alcohol dependence.
FAU - Joe, Keun-Ho
AU  - Joe KH
AD  - Department of Social Welfare with Addiction Rehabilitation, Eulji University, 
      Daejeon, Korea.
FAU - Kim, Yong-Ku
AU  - Kim YK
FAU - Kim, Tae-Suk
AU  - Kim TS
FAU - Roh, Sung-Won
AU  - Roh SW
FAU - Choi, Sam-Wook
AU  - Choi SW
FAU - Kim, Young-Bo
AU  - Kim YB
FAU - Lee, Hee-Jin
AU  - Lee HJ
FAU - Kim, Dai-Jin
AU  - Kim DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070911
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/blood
MH  - Alcoholism/*blood/genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Health Surveys
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
EDAT- 2007/09/14 09:00
MHDA- 2008/01/23 09:00
CRDT- 2007/09/14 09:00
PHST- 2007/09/14 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/09/14 09:00 [entrez]
AID - ACER507 [pii]
AID - 10.1111/j.1530-0277.2007.00507.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2007 Nov;31(11):1833-8. doi: 
      10.1111/j.1530-0277.2007.00507.x. Epub 2007 Sep 11.