PMID- 17851835
OWN - NLM
STAT- MEDLINE
DCOM- 20080421
LR  - 20220330
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 46
IP  - 8
DP  - 2007
TI  - Interleukin-18 gene promoter polymorphisms and the risk of esophageal squamous 
      cell carcinoma.
PG  - 1090-6
AB  - BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is multifactorial, and the 
      genetic background may be a crucial etiologic factor. Interleukin-18 (IL-18) is a 
      multifunctional cytokine that induces interferon (IFN)-gamma secretion and plays 
      an important role in antitumor immunity. Variations in the DNA sequence in the 
      IL-18 gene promoter may lead to altered IL-18 production and/or activity, and so 
      this can modulate an individual's susceptibility to ESCC. To test this 
      hypothesis, we investigated the relationship of IL-18 gene promoter -137 G/C and 
      -607 C/A polymorphisms and their haplotypes with the risk of ESCC in a Chinese 
      population. METHODS: Two hundred and thirty five patients with ESCC and 250 age- 
      and sex-matched controls, using sequence specific primers-polymerase chain 
      reaction (PCR-SSP). RESULTS: Two polymorphisms, -137 G/C and -607 C/A were in 
      strong linkage disequilibrium (LD). There were significantly differences in the 
      genotype and allele distribution of -137 G/C polymorphism of the IL-18 gene among 
      cases and controls. The -137 GC and CC genotypes were associated with a 
      significantly increased risk of ESCC as compared with the -137 GG genotypes (OR = 
      1.91, 95% CI, 1.29-2.82, p = 0.001 and OR = 2.95, 95% CI, 1.23-7.04, p = 0.012, 
      respectively). Consistent with the results of the genotyping analyses, the -137 
      C/ -607 A haplotype was associated with a significantly increased risk of ESCC as 
      compared with the -137G/-607 C haplotype (OR = 1.61; 95% CI, 1.16-2.23; p = 
      0.004). CONCLUSION: This study shows for the first time an association between 
      IL-18 gene promoter -137 G/C polymorphism may contribute represent a genetic risk 
      factor for ESCC in a Chinese population.
FAU - Wei, Ye-Sheng
AU  - Wei YS
AD  - Center of Clinical Laboratory, Affiliated Hospital of Youjiang Medical College 
      for Nationalities, Baise 533000, Guangxi, People's Republic of China. 
      wysh22@163.com
FAU - Lan, Yan
AU  - Lan Y
FAU - Liu, Yun-Guang
AU  - Liu YG
FAU - Tang, Hui
AU  - Tang H
FAU - Tang, Ren-Guang
AU  - Tang RG
FAU - Wang, Jian-Chu
AU  - Wang JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Esophageal Neoplasms/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Severity of Illness Index
EDAT- 2007/09/14 09:00
MHDA- 2008/04/22 09:00
CRDT- 2007/09/14 09:00
PHST- 2007/09/14 09:00 [pubmed]
PHST- 2008/04/22 09:00 [medline]
PHST- 2007/09/14 09:00 [entrez]
AID - 778813007 [pii]
AID - 10.1080/02841860701373595 [doi]
PST - ppublish
SO  - Acta Oncol. 2007;46(8):1090-6. doi: 10.1080/02841860701373595.