PMID- 17852040
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20221207
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 39
IP  - 6
DP  - 2007
TI  - Triggers of IgE class switching and allergy development.
PG  - 440-56
AB  - The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been 
      increasing for the last four decades. In this review determinants for an 
      increased IgE synthesis are discussed on both an epidemiological and on an 
      immunological level with special emphasis on the differentiation of the B cell to 
      an IgE-producing plasma cell. Factors that favor an IgE immune response are low 
      antigen doses and immunization via mucous membranes, but it is highly likely that 
      other environmental factors besides exposure to the allergenic sources play a 
      role. Important factors in the formation of the Thelper type 2 (Th2) T cell 
      subset are the actions of thymic stromal lymphopoietin (TSLP) on dendritic cells 
      and the OX40 ligand on CD4+ T cells. In order for a B lymphocyte to switch to IgE 
      production it needs two signals provided by a Th2 cell in the form of the 
      cytokines interleukin (IL-) 4/IL-13 and ligation of the CD40. In spite of a 
      half-life of only a few days, there is evidence that the IgE response may last 
      for years even without allergen stimulation. This is likely to be caused by 
      long-lived IgE-producing plasma cells, and such cells may be difficult to target 
      therapeutically thus emphasizing the need for more knowledge on preventable 
      causes of IgE- and allergy development.
FAU - Poulsen, Lars K
AU  - Poulsen LK
AD  - Laboratory of Medical Allergology, Allergy Clinic, National University Hospital, 
      Copenhagen, Denmark. lkpallgy@mail.dk
FAU - Hummelshoj, Lone
AU  - Hummelshoj L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070706
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-3)
RN  - 0 (OX40 Ligand)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/physiology
MH  - CD4-Positive T-Lymphocytes/immunology/physiology
MH  - CD40 Antigens/immunology
MH  - Cell Differentiation
MH  - Cytokines/metabolism
MH  - Dendritic Cells/immunology/physiology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - *Immunoglobulin Class Switching
MH  - Immunoglobulin E/biosynthesis/*immunology
MH  - Interleukin-13/metabolism
MH  - Interleukin-3/metabolism
MH  - Mice
MH  - OX40 Ligand/metabolism
MH  - Thymic Stromal Lymphopoietin
RF  - 159
EDAT- 2007/09/14 09:00
MHDA- 2008/01/30 09:00
CRDT- 2007/09/14 09:00
PHST- 2007/09/14 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2007/09/14 09:00 [entrez]
AID - 780467545 [pii]
AID - 10.1080/07853890701449354 [doi]
PST - ppublish
SO  - Ann Med. 2007;39(6):440-56. doi: 10.1080/07853890701449354. Epub 2007 Jul 6.