PMID- 17852047
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20220330
IS  - 0148-5016 (Print)
IS  - 0148-5016 (Linking)
VI  - 53
IP  - 4
DP  - 2007 Jul-Aug
TI  - Spermatozoa and chronic treatment with finasteride: a TEM and FISH study.
PG  - 229-33
AB  - Finasteride is a specific inhibitor of the 5alpha reductase enzyme originally 
      approved for the treatment of benign prostatic hypertrophy and also for the 
      treatment of androgenetic alopecia (AGA) in men at a dose of 1 mg/day. We report 
      on three cases of young men recruited at our Centre for Male Infertility who had 
      used finasteride for five years. Semen quality was investigated by light 
      microscopy to evaluate sperm concentration and motility. Sperm morphology was 
      performed by transmission electron microscope (TEM) and the data were analyzed. 
      The presence of Y microdeletions was investigated by PCR. Meiotic segregation was 
      explored by fluorescence in situ hybridization (FISH). Patient 1 was azoospermic, 
      patients 2 and 3 showed a normal sperm concentration and severely reduced 
      progressive motility. TEM analysis revealed altered sperm morphology consistent 
      with necrosis and FISH data revealed elevated diploidy and sex chromosome disomy 
      frequencies. This examination was repeated 1 year after the men had suspended the 
      use of finasteride, without receiving any other treatment. A recovery of 
      spermatogenetic process was observed. Motility and morphology improved whereas 
      the meiotic pattern did not change presenting elevated diploidy and sex 
      chromosome disomy frequency.
FAU - Collodel, Giulia
AU  - Collodel G
AD  - Department of Surgery, Biology Section, Interdepartmental Centre for Research and 
      Therapy of Male Infertility, University of Siena, Policlinico Le Scotte, Viale 
      Bracci 14, 53100 Siena, Italy.
FAU - Scapigliati, Giacomo
AU  - Scapigliati G
FAU - Moretti, Elena
AU  - Moretti E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Arch Androl
JT  - Archives of andrology
JID - 7806755
RN  - 57GNO57U7G (Finasteride)
SB  - IM
MH  - Adult
MH  - Alopecia/drug therapy
MH  - Aneuploidy
MH  - Diploidy
MH  - Finasteride/*adverse effects
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/chemically induced
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Spermatozoa/*drug effects/pathology
EDAT- 2007/09/14 09:00
MHDA- 2007/10/20 09:00
CRDT- 2007/09/14 09:00
PHST- 2007/09/14 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2007/09/14 09:00 [entrez]
AID - 781950630 [pii]
AID - 10.1080/01485010701426471 [doi]
PST - ppublish
SO  - Arch Androl. 2007 Jul-Aug;53(4):229-33. doi: 10.1080/01485010701426471.