PMID- 17853300
OWN - NLM
STAT- MEDLINE
DCOM- 20080926
LR  - 20151119
IS  - 1562-2975 (Print)
IS  - 1562-2975 (Linking)
VI  - 9
IP  - 2
DP  - 2008
TI  - Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met 
      variant in obsessive-compulsive disorder (OCD).
PG  - 126-34
AB  - Although evidence from family studies suggest that genetic factors play an 
      important role in mediating obsessive-compulsive disorder (OCD), results from 
      genetic case-control association analyses have been inconsistent. Discrepant 
      findings may be attributed to the lack of phenotypic resolution, and population 
      stratification. The aim of the present study was to investigate the role that the 
      val66met variant within the gene encoding brain-derived neurotrophic factor 
      (BDNF) may play in mediating the development of selected OCD subtypes accounting 
      for the aforementioned confounding factors. One hundred and twelve OCD subjects 
      and 140 controls were selected from the South African Afrikaner population. A 
      significant association was observed in the male subgroup, with the met66 allele 
      implicated as the risk allele in the development of OCD. This allele was also 
      found to be associated with an earlier age at onset of OCD in males. On the other 
      hand, the val66val genotype was associated with more severe OCD in the female 
      population. No evidence of population stratification was observed in Afrikaner 
      control subjects. These preliminary results point towards genetically distinct 
      characteristics of OCD mediated by dysfunctions in BDNF. The present 
      investigation forms part of ongoing research to elucidate the genetic components 
      involved in the aetiology of OCD and OCD-related characteristics.
FAU - Hemmings, Sian M J
AU  - Hemmings SM
AD  - MRC/US Centre for Molecular and Cellular Biology, University of Stellenbosch, 
      Tygerberg, South Africa. smjh@sun.ac.za
FAU - Kinnear, Craig J
AU  - Kinnear CJ
FAU - Van der Merwe, Lize
AU  - Van der Merwe L
FAU - Lochner, Christine
AU  - Lochner C
FAU - Corfield, Valerie A
AU  - Corfield VA
FAU - Moolman-Smook, Johanna C
AU  - Moolman-Smook JC
FAU - Stein, Dan J
AU  - Stein DJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Chromosome Aberrations
MH  - Female
MH  - Genetic Markers
MH  - Genetic Variation/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Obsessive-Compulsive Disorder/diagnosis/ethnology/*genetics
MH  - Population Surveillance
MH  - South Africa
MH  - Surveys and Questionnaires
EDAT- 2007/09/14 09:00
MHDA- 2008/09/27 09:00
CRDT- 2007/09/14 09:00
PHST- 2007/09/14 09:00 [pubmed]
PHST- 2008/09/27 09:00 [medline]
PHST- 2007/09/14 09:00 [entrez]
AID - 773142631 [pii]
AID - 10.1080/15622970701245003 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2008;9(2):126-34. doi: 10.1080/15622970701245003.