PMID- 17854427
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 5
DP  - 2007 Nov
TI  - 14 bp deletion polymorphism in the HLA-G gene is a risk factor for idiopathic 
      dilated cardiomyopathy in a Chinese Han population.
PG  - 427-31
AB  - Human leukocyte antigen (HLA) has been reported to be associated with the 
      pathogenesis of autoimmune-associated idiopathic dilated cardiomyopathy (IDC). 
      However, the HLA-G in this context is limited. In the current study, a total of 
      117 IDC patients and age and sex matched 401 unrelated healthy controls in a 
      Chinese Han population were HLA-G genotyped for the 14 bp insertion and deletion 
      polymorphism. IDC patients showed markedly increased frequencies of -14 bp/-14 bp 
      genotype [Pc = 0.00049, odds ratio (OR) = 2.17] and -14 bp alleles (Pc = 4.1 x 
      10(-5), OR = 1.97) when compared with healthy controls. Whereas the frequencies 
      of +14 bp/+14 bp genotype (Pc = 0.0036, OR = 0.35) and +14 bp alleles (Pc = 4.1 x 
      10(-5), OR = 0.51) were significantly lower in IDC. These data, for the first 
      time, indicated that 14 bp insertion/deletion polymorphism in HLA-G gene could be 
      a genetic risk factor for the susceptibility to IDC.
FAU - Lin, A
AU  - Lin A
AD  - Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      College, Linhai, Zhejiang, China.
FAU - Yan, W H
AU  - Yan WH
FAU - Xu, H H
AU  - Xu HH
FAU - Tang, L J
AU  - Tang LJ
FAU - Chen, X F
AU  - Chen XF
FAU - Zhu, M
AU  - Zhu M
FAU - Zhou, M Y
AU  - Zhou MY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070914
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Autoimmune Diseases/*genetics
MH  - Base Sequence
MH  - Cardiomyopathy, Dilated/*genetics
MH  - China
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *INDEL Mutation
MH  - Male
MH  - Middle Aged
MH  - Mutagenesis, Insertional
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Sequence Deletion
EDAT- 2007/09/15 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/09/15 09:00
PHST- 2007/09/15 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/09/15 09:00 [entrez]
AID - TAN926 [pii]
AID - 10.1111/j.1399-0039.2007.00926.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Nov;70(5):427-31. doi: 10.1111/j.1399-0039.2007.00926.x. 
      Epub 2007 Sep 14.