PMID- 17854666
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 177
IP  - 2
DP  - 2007 Sep
TI  - Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia.
PG  - 120-4
AB  - Translocations involving 21q22 are commonly observed in both de novo and 
      therapy-related acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). 
      They often result in the disruption of RUNX1 and give rise to fusion genes 
      consisting of RUNX1 and different partner genes, which contribute to 
      leukemogenesis. To date, at least 21 such translocations are known from the 
      literature. Here we report two novel translocations involving the RUNX1 gene: 
      t(1;21)(q12;q22) in a 53-year-old woman with AML-M5b and t(11;21)(q13;q22) in a 
      65-year-old man with AML-M2. The abnormalities revealed by R-banding karyotypic 
      analysis were confirmed with interphase and metaphase fluorescence in situ 
      hybridization (FISH), chromosome painting, and M-FISH.
FAU - Dai, Haiping
AU  - Dai H
AD  - Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, 
      188 Shizi Street, 215006 Suzhou, People's Republic of China.
FAU - Xue, Yongquan
AU  - Xue Y
FAU - Pan, Jinlan
AU  - Pan J
FAU - Wu, Yafang
AU  - Wu Y
FAU - Wang, Yong
AU  - Wang Y
FAU - Shen, Juan
AU  - Shen J
FAU - Zhang, Jun
AU  - Zhang J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (RUNX1 protein, human)
SB  - IM
MH  - Aged
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 21/genetics
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Monocytic, Acute/*genetics
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 2007/09/15 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/09/15 09:00
PHST- 2007/02/21 00:00 [received]
PHST- 2007/04/02 00:00 [revised]
PHST- 2007/05/15 00:00 [accepted]
PHST- 2007/09/15 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/09/15 09:00 [entrez]
AID - S0165-4608(07)00314-7 [pii]
AID - 10.1016/j.cancergencyto.2007.04.018 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Sep;177(2):120-4. doi: 
      10.1016/j.cancergencyto.2007.04.018.